Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 7/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268342 | 1.00 | GHSR (0.45) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL7368069 | 0.90 | GHSR (0.49) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL4428281 | 0.90 | GHSR (0.49) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL3273825 | 0.89 | GHSR (0.47) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL3266509 | 0.88 | GHSR (0.46) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL6317705 | 0.87 | GHSR (0.48) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL3266715 | 0.87 | MMP13 (0.48) | CTSBCTSSCTSKMMP13REN | |
| SCHEMBL6323778 | 0.86 | CTSB (0.44) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL6323772 | 0.86 | CTSB (0.44) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL3266843 | 0.85 | GHSR (0.47) | GHSRCTSBCTSSCTSKMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |