SCHEMBL7368069

SCHEMBL7368069

CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)C(Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 7/20 0.49
CTSB P07858 1/20 0.46
CTSS P25774 1/20 0.46
CTSK P43235 1/20 0.46
FCER2 P06734 2/20 0.44
REN P00797 1/20 0.42
MMP13 P45452 1/20 0.41
MMP9 P14780 1/20 0.40
MMP8 P22894 1/20 0.40
PTPN1 P18031 1/20 0.39
MAOB P27338 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4428281 1.00 GHSR (0.49) GHSRCTSBCTSSCTSKFCER2
SCHEMBL8717973 0.93 GHSR (0.43) GHSRCTSBCTSSCTSKFCER2
SCHEMBL6317980 0.93 GHSR (0.43) GHSRCTSBCTSSCTSKFCER2
SCHEMBL3273825 0.91 GHSR (0.47) GHSRCTSBCTSSCTSKREN
SCHEMBL6317705 0.90 GHSR (0.48) GHSRCTSBCTSSCTSKREN
SCHEMBL6317662 0.90 PTPN1 (0.45) GHSRCTSBCTSSCTSKFCER2
SCHEMBL3273983 0.90 GHSR (0.45) GHSRCTSBCTSSCTSKREN
SCHEMBL3268342 0.90 GHSR (0.45) GHSRCTSBCTSSCTSKREN
SCHEMBL3266843 0.88 GHSR (0.47) GHSRCTSBCTSSCTSKMMP13
SCHEMBL6318464 0.88 CTSB (0.45) GHSRCTSBCTSSCTSKREN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1093463-A1 A METHOD FOR PREPARING A COMPOUND WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 2001-04-25 EP disclosed
EP-1060190-A1 NEW SALT FORMS OF (2E)- 5-AMINO-5- METHYLHEX-2- ENOIC ACID N-METHYL-N-((1R)-1-(N- METHYL-N-((1R)-1-(METHYLCARBAMOYL)-2- PHENYLETHYL)CARBAMOYL)-2- (2-NAPHTYL)ETHYL)AMIDE NOVO NORDISK A/S (DK) 2000-12-20 EP disclosed
WO-1999064456-A1 A METHOD FOR PREPARING A COMPOUND WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1999-12-16 WO disclosed
EP-0941115-A1 USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION NOVO NORDISK A/S (DK) 1999-09-15 EP disclosed
WO-1999045029-A1 NEW SALT FORMS OF (2E)- 5-AMINO-5- METHYLHEX-2- ENOIC ACID N-METHYL-N-((1R)-1-(N- METHYL-N-((1R)-1-(METHYLCARBAMOYL)-2- PHENYLETHYL)CARBAMOYL)-2- (2-NAPHTYL)ETHYL)AMIDE NOVO NORDISK A/S (DK) 1999-09-10 WO disclosed
WO-1998019699-A1 USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION NOVO NORDISK A/S (DK) 1998-05-14 WO disclosed