Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 7/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | FCER2 | P06734 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368069 | 1.00 | GHSR (0.49) | GHSRCTSBCTSSCTSKFCER2 | |
| SCHEMBL8717973 | 0.93 | GHSR (0.43) | GHSRCTSBCTSSCTSKFCER2 | |
| SCHEMBL6317980 | 0.93 | GHSR (0.43) | GHSRCTSBCTSSCTSKFCER2 | |
| SCHEMBL3273825 | 0.91 | GHSR (0.47) | GHSRCTSBCTSSCTSKREN | |
| SCHEMBL6317705 | 0.90 | GHSR (0.48) | GHSRCTSBCTSSCTSKREN | |
| SCHEMBL6317662 | 0.90 | PTPN1 (0.45) | GHSRCTSBCTSSCTSKFCER2 | |
| SCHEMBL3273983 | 0.90 | GHSR (0.45) | GHSRCTSBCTSSCTSKREN | |
| SCHEMBL3268342 | 0.90 | GHSR (0.45) | GHSRCTSBCTSSCTSKREN | |
| SCHEMBL3266843 | 0.88 | GHSR (0.47) | GHSRCTSBCTSSCTSKMMP13 | |
| SCHEMBL6318464 | 0.88 | CTSB (0.45) | GHSRCTSBCTSSCTSKREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869974-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2009-03-04 | — | — | EP | disclosed |
| US-6939880-B2 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-09-06 | — | — | US | disclosed |
| US-6784158-B1 | SECRETAGOGUE WHICH CAN BE USED IN TREATING MEDICAL DISORDERS RESULTING FROM A DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2004-08-31 | — | — | US | disclosed |
| US-20040063641-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | RASCHKE MICHAEL (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1060190-B1 | NEW SALT FORMS OF (2E)- 5-AMINO-5- METHYLHEX-2- ENOIC ACID N-METHYL-N-((1R)-1-(N- METHYL-N-((1R)-1-(METHYLCARBAMOYL)-2- PHENYLETHYL)CARBAMOYL)-2- (2-NAPHTYL)ETHYL)AMIDE | NOVO NORDISK AS (DK) | 2003-11-19 | — | — | EP | disclosed |
| US-6555570-B2 | Growth hormone secretagogous with improved bioavailability | NOVO NORDISK A/S (DE) | 2003-04-29 | — | — | US | disclosed |
| US-20030055261-A1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS (U.S.), INC. | 2003-03-20 | — | — | US | disclosed |
| US-20030040483-A1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS (U.S.), INC. | 2003-02-27 | — | — | US | disclosed |
| US-20020128178-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | RASCHKE MICHAEL (DE) | 2002-09-12 | — | — | US | disclosed |
| US-6281247-B1 | GLANDULAR DISORDERS; ANIMAL GROWTH REGULATORS | NOVO NORDISK A/S (DK) | 2001-08-28 | — | — | US | disclosed |
| US-6127391-A | A PEPTIDE MIMETIC COMPOUND FOR STIMULATING THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY | NOVO NORDISK A/S (DK) | 2000-10-03 | — | — | US | disclosed |
| WO-1999064456-A1 | A METHOD FOR PREPARING A COMPOUND WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-12-16 | — | — | WO | disclosed |
| US-5977178-A | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 1999-11-02 | — | — | US | disclosed |
| EP-0941115-A1 | USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION | NOVO NORDISK A/S (DK) | 1999-09-15 | — | — | EP | disclosed |
| WO-1999045029-A1 | NEW SALT FORMS OF (2E)- 5-AMINO-5- METHYLHEX-2- ENOIC ACID N-METHYL-N-((1R)-1-(N- METHYL-N-((1R)-1-(METHYLCARBAMOYL)-2- PHENYLETHYL)CARBAMOYL)-2- (2-NAPHTYL)ETHYL)AMIDE | NOVO NORDISK A/S (DK) | 1999-09-10 | — | — | WO | disclosed |
| EP-0907374-A1 | GROWTH HORMONE COMPONENT AND BONE ANTI-RESORPTIVE AGENT IN CYCLIC (COHERENCE) TREATMENT OF OSTEOPOROSIS | NOVO NORDISK A/S (DK) | 1999-04-14 | — | — | EP | disclosed |
| EP-0869974-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1998-10-14 | — | — | EP | disclosed |
| WO-1998019699-A1 | USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION | NOVO NORDISK A/S (DK) | 1998-05-14 | — | — | WO | disclosed |
| WO-1997046252-A1 | GROWTH HORMONE COMPONENT AND BONE ANTI-RESORPTIVE AGENT IN CYCLIC (COHERENCE) TREATMENT OF OSTEOPOROSIS | NOVO NORDISK A/S (DK) | 1997-12-11 | — | — | WO | disclosed |
| WO-1997023508-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1997-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055261-A1 | Compounds with growth hormone releasing properties | GHRHR, GHSR, IGFBP1 | GHSR 2/4885CTSB 967/4885CTSS 2319/4885 |
| US-20040063641-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | GHSR, GHRHR, BMP2 | GHSR 1/4885CTSB 142/4885CTSS 298/4885 |
| US-20030040483-A1 | Compounds with growth hormone releasing properties | GHRHR, GHSR, GRPR | GHSR 2/4885CTSB 1232/4885CTSS 2636/4885 |
| US-20020128178-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | GHSR, GHRHR, BMP2 | GHSR 1/4885CTSB 142/4885CTSS 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.