Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000827 | 0.94 | PDE1C (0.45) | ADORA2BALDH1A1PDE1CADORA3 | |
| SCHEMBL4260613 | 0.92 | ADORA2B (0.57) | ADORA2BALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3004313 | 0.82 | ALDH1A1 (0.56) | ADORA2BALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3002847 | 0.79 | PDE1C (0.54) | ALDH1A1KDM4EPDE1CADORA3 | |
| SCHEMBL3242915 | 0.76 | PDE1C (0.48) | MEN1KMT2APDE1CADORA3 | |
| SCHEMBL3241017 | 0.73 | PDE1C (0.59) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL2996950 | 0.72 | PDE1C (0.45) | PDE1CADORA3 | |
| SCHEMBL7696472 | 0.72 | ALDH1A1 (0.54) | ADORA2BALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3006899 | 0.71 | PDE1C (0.44) | ALDH1A1KDM4EPDE1CADORA3 | |
| SCHEMBL3237974 | 0.69 | TSHR (0.44) | MAPTPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |