Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690962 | 0.82 | ALDH1A1 (0.66) | ALDH1A1ADORA2BALOX12MAPTDHFR | |
| SCHEMBL7689428 | 0.82 | ADORA2B (0.78) | ALDH1A1ADORA2BALOX12TP53HSP90AA1 | |
| SCHEMBL14164070 | 0.81 | DHFR (0.79) | ALDH1A1ADORA2BALOX12TP53HSP90AA1 | |
| SCHEMBL7697262 | 0.80 | ALDH1A1 (0.61) | ALDH1A1ADORA2BALOX12MAPTHTT | |
| SCHEMBL7691974 | 0.79 | CA1 (0.56) | ALDH1A1ADORA2BALOX12TP53HSP90AA1 | |
| SCHEMBL7701429 | 0.77 | TP53 (0.80) | ALDH1A1ALOX12TP53HSP90AA1MAPT | |
| SCHEMBL31541594 | 0.77 | DHFR (0.67) | ALDH1A1ADORA2BALOX12TP53HSP90AA1 | |
| SCHEMBL3000827 | 0.77 | PDE1C (0.45) | ALDH1A1ADORA2B | |
| SCHEMBL14164069 | 0.76 | DHFR (0.66) | ALDH1A1ADORA2BALOX12TP53HSP90AA1 | |
| SCHEMBL7695774 | 0.76 | CA1 (0.70) | ALDH1A1ALOX12TP53HSP90AA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | claimed |
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |