Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13215735 | 0.85 | KMT2A (0.59) | KMT2APOLBALDH1A1LMNACYP3A4 | |
| SCHEMBL2338220 | 0.82 | CA2 (0.52) | KMT2APOLBALDH1A1ESR1ESR2 | |
| SCHEMBL498617 | 0.82 | ALDH1A1 (0.56) | POLBALDH1A1MMP12MMP13TSHR | |
| SCHEMBL13870211 | 0.81 | KMT2A (1.00) | KMT2APOLBALDH1A1APEX1CYP3A4 | |
| SCHEMBL4400952 | 0.81 | KMT2A (0.62) | KMT2APOLBALDH1A1LMNACYP3A4 | |
| SCHEMBL3237371 | 0.81 | TSHR (0.56) | KMT2APOLBALDH1A1MMP12MMP13 | |
| SCHEMBL2337040 | 0.81 | KMT2A (0.46) | KMT2APOLBALDH1A1MMP12MMP13 | |
| SCHEMBL1137128 | 0.81 | LMNA (0.47) | KMT2APOLBALDH1A1LMNAMMP12 | |
| SCHEMBL831127 | 0.81 | KMT2A (0.51) | KMT2APOLBLMNAMMP12MMP13 | |
| SCHEMBL2338295 | 0.81 | KMT2A (0.46) | KMT2APOLBALDH1A1MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292308-B1 | ALPHA,BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1292308-A4 | ALPHA,BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2005-09-14 | — | — | EP | disclosed |
| US-6599932-B1 | Highly selective in killing tumor cells but not normal cells | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-07-29 | — | — | US | disclosed |
| US-20030130339-A1 | ALPHA, BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS | REDDY E PREMKUMAR (US) | 2003-07-10 | — | — | US | disclosed |
| US-6541475-B2 | 2-nitrostyryl-1-(naphthylmethyl)sulfone for example | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-04-01 | — | — | US | disclosed |
| EP-1292308-A1 | ALPHA,BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20020028818-A1 | Alpha, beta-unsaturated sulfones for treating proliferative disorders | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2002-03-07 | — | — | US | disclosed |
| WO-2001078733-A1 | ALPHA,BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028818-A1 | Alpha, beta-unsaturated sulfones for treating proliferative disorders | QSOX1, CBR1, DEGS1 | KMT2A 3686/4885POLB 749/4885ALDH1A1 738/4885 |
| US-20030130339-A1 | ALPHA, BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS | QSOX1, CCNY, CBR1 | KMT2A 3637/4885POLB 815/4885ALDH1A1 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.