SCHEMBL32680262

SCHEMBL32680262

O=Cc1nncn1-c1cccc(F)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 4/20 0.46
KDM4E B2RXH2 1/20 0.35
P2RX7 Q99572 3/20 0.33
CCKBR P32239 1/20 0.33
KCNN4 O15554 1/20 0.32
ERN1 O75460 1/20 0.31
NFE2L2 Q16236 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32680206 0.84 P2RX7 (0.45) HCAR1P2RX7
SCHEMBL30431522 0.70 FGFR1 (0.46) HCAR1
SCHEMBL32680303 0.70 NOTUM (0.47) HCAR1KDM4EP2RX7KCNN4
SCHEMBL4825732 0.67 ALDH1A1 (0.41) HCAR1KDM4E
SCHEMBL27441274 0.64 ERN1 (0.41) HCAR1ERN1NFE2L2
SCHEMBL23927212 0.64 OPRK1 (0.43) HCAR1
SCHEMBL29519637 0.63 ERN1 (0.57) ERN1NFE2L2
SCHEMBL561472 0.63 ERN1 (0.57) ERN1NFE2L2
Formic Acid SCHEMBL27440103 0.62 ERN1 (0.45) ERN1
SCHEMBL28084075 0.61 CYP3A4 (0.53) HCAR1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4702017-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd (KY) 2026-03-04 EP disclosed