SCHEMBL561472

SCHEMBL561472

O=Cc1cccc(F)c1Cl

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 2/20 0.57
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
TDP1 Q9NUW8 3/20 0.46
LMNA P02545 1/20 0.46
THRB P10828 1/20 0.46
BLM P54132 1/20 0.46
NFE2L2 Q16236 5/20 0.41
ALDH1A1 P00352 3/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TRIM24 O15164 2/20 0.38
TRIM33 Q9UPN9 2/20 0.38
TSHR P16473 1/20 0.38
CYP2A6 P11509 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29519637 1.00 ERN1 (0.57) ERN1MEN1KMT2ATDP1LMNA
SCHEMBL3794351 0.83 TDP1 (0.58) ERN1MEN1KMT2ATDP1LMNA
SCHEMBL3452795 0.81 NFE2L2 (0.44) ERN1NFE2L2
SCHEMBL30828536 0.81 ERN1 (0.42) ERN1MEN1KMT2ATDP1LMNA
SCHEMBL7009789 0.79 ALDH1A1 (0.53) ERN1MEN1KMT2ATDP1LMNA
SCHEMBL6495322 0.79 TDP1 (0.46) ERN1MEN1KMT2ATDP1LMNA
SCHEMBL5412890 0.77 NFE2L2 (0.41) ERN1NFE2L2
SCHEMBL16960014 0.77 ERN1 (0.42) ERN1NFE2L2
SCHEMBL9245050 0.77 ALDH1A1 (0.48) ERN1NFE2L2ALDH1A1
SCHEMBL30011286 0.76 ALDH1A1 (0.54) ERN1MEN1KMT2ATDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 363 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118496215-A Polyhydroxylated onium derivative with disubstituted benzene ring, preparation method and medical application thereof 中国药科大学 2024-08-16 CN claimed
CN-117624148-A Polyhydroxy sulfonium salt derivative with disubstituted benzene ring, preparation method and medical application thereof 中国药科大学 2024-03-01 CN claimed
CN-109312618-A For hydraulic fracturing and for the method and composition of tracer water flooding 光谱追踪服务有限责任公司 2019-02-05 CN claimed
CN-107286549-A Antibacterial resin and preparation method thereof 立得光电科技股份有限公司 2017-10-24 CN claimed
CN-106892803-A The preparation method of the fluorobenzaldehyde of 2,6 dichloro 3 and the preparation method of fluorine quinolone compounds 浙江朗华制药有限公司 2017-06-27 CN claimed
CN-102532640-B Method of nucleating polyolefin composition with acetal-based compound MILLIKEN & CO 2014-11-26 CN claimed
CN-103429594-A Process for preparation of acetals RELIANCE IND LTD 2013-12-04 CN claimed
CN-103415523-A Process for preparing alditol acetals RELIANCE IND LTD 2013-11-27 CN claimed
JP-60038336-A None JP disclosed
EP-4747234-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
EP-4747235-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
US-20260116857-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS PARDES BIOSCIENCES INC (US) 2026-04-30 US disclosed
US-12454502-B2 Synthesis of deuterated aldehydes ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIVERSITY OF ARIZONA (US) 2025-10-28 US disclosed
EP-4626554-A1 GLUTARIMIDE-CONTAINING KRAS-MUTANT DEGRADER COMPOUNDS AND USES THEREOF Tiger Biotherapeutics Inc. (US) 2025-10-08 EP disclosed
WO-1992004025-A1 AMINO ACID ANALOGS AS CCK ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1992-03-19 WO disclosed
US-4647565-A 2-(2-quinazolinylaminoalkoxymethyl)-1,4-dihydropyridine derivatives as cardiovascular agents PFIZER INC. (US) 1987-03-03 US disclosed
US-4578395-A Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive TEIJIN LIMITED (JP) 1986-03-25 US disclosed
EP-0168151-A1 Dihydropyridine cardiovascular agents Pfizer Limited (GB) 1986-01-15 EP disclosed
JP-S6038336-A BENZALDEHYDE DERIVATIVE AND ITS PREPARATION TEIJIN LTD 1985-02-27 JP disclosed
EP-0128010-A2 1,4-Dihydropyridine derivative, process for production thereof and pharmaceutical use thereof TEIJIN LIMITED (JP) 1984-12-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260116857-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS CTRC, CTRL, CTSL ERN1 607/4885MEN1 4346/4885KMT2A 4265/4885
US-12454502-B2 Synthesis of deuterated aldehydes ADH1C, ADH1A, CBR1 ERN1 810/4885MEN1 2298/4885KMT2A 1248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.