SCHEMBL32684019

SCHEMBL32684019

NC(=O)Cc1c[nH]c2c(Cl)cccc12

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.60
MPO P05164 3/20 0.50
SLC6A4 P31645 1/20 0.50
NR4A2 P43354 1/20 0.49
ICMT O60725 4/20 0.47
RIPK1 Q13546 3/20 0.47
GAA P10253 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
AHR P35869 1/20 0.46
PCSK9 Q8NBP7 2/20 0.46
DYRK1A Q13627 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8088111 1.00 HTR2A (0.60) HTR2AMPOSLC6A4NR4A2ICMT
SCHEMBL6516641 0.86 HTR2A (0.58) HTR2ASLC6A4NR4A2RIPK1GAA
SCHEMBL25139842 0.82 HTR2A (0.54) HTR2ASLC6A4NR4A2RIPK1AHR
SCHEMBL25139668 0.82 HTR2A (0.54) HTR2ASLC6A4NR4A2RIPK1AHR
SCHEMBL3611008 0.81 HTR2A (0.60) HTR2AMPONR4A2ICMTGAA
SCHEMBL32684012 0.81 MPO (0.50) MPOSLC6A4ICMTGAANPSR1
SCHEMBL1973303 0.81 MPO (0.74) HTR2AMPOSLC6A4ICMTRIPK1
SCHEMBL20588278 0.78 HTR2A (0.75) HTR2AMPOSLC6A4NR4A2RIPK1
SCHEMBL13715436 0.78 HTR2A (0.65) HTR2ASLC6A4NR4A2RIPK1AHR
SCHEMBL5163846 0.78 CSNK2A2 (0.50) MPOICMTGAANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260071243-A1 BIOLOGICAL PRODUCTION OF TRYPTOPHAN-DERIVED PRODUCTS UNIV TEXAS (US) 2026-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260071243-A1 BIOLOGICAL PRODUCTION OF TRYPTOPHAN-DERIVED PRODUCTS TPH1, TPH2, SLC6A4 HTR2A 8/4885MPO 1194/4885SLC6A4 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.