SCHEMBL32688064

SCHEMBL32688064

CCOC(=O)c1cccc(CSc2[nH]c(=O)cc(-c3cccc(C(=O)Nc4ccccc4)c3)c2C#N)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ACMSD Q8TDX5 3/20 0.52
▸ KMT2A Q03164 4/20 0.50
▸ POLB P06746 4/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ RAB9A P51151 4/20 0.43
▸ NPC1 O15118 3/20 0.43
▸ MAPT P10636 4/20 0.43
▸ LMNA P02545 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.42
▸ HPGD P15428 1/20 0.42
▸ SMN1; SMN2 Q16637 3/20 0.42
▸ GAA P10253 2/20 0.42
▸ ROCK2 O75116 1/20 0.41
▸ SIRT2 Q8IXJ6 1/20 0.41
▸ PKM P14618 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ SENP1 Q9P0U3 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23183542 0.90 ACMSD (0.57) ACMSDKMT2APOLBMEN1RAB9A
SCHEMBL32688009 0.89 ACMSD (0.54) ACMSDKMT2APOLBMEN1ALDH1A1
SCHEMBL32688164 0.86 KMT2A (0.47) ACMSDKMT2APOLBMEN1RAB9A
SCHEMBL32688394 0.86 NR1H4 (0.48) ACMSDKMT2APOLBMEN1ALDH1A1
SCHEMBL20339582 0.83 KMT2A (0.64) ACMSDKMT2APOLBMEN1RAB9A
SCHEMBL32688306 0.82 KMT2A (0.59) ACMSDKMT2APOLBMEN1RAB9A
SCHEMBL32688277 0.81 KMT2A (0.52) KMT2APOLBMEN1RAB9ANPC1
SCHEMBL32688124 0.81 ACMSD (0.42) ACMSDKMT2APOLBMEN1RAB9A
SCHEMBL32688364 0.81 KMT2A (0.51) KMT2APOLBMEN1RAB9ANPC1
SCHEMBL20350857 0.79 ACMSD (0.56) ACMSDKMT2APOLBMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK ACMSD 142/4885KMT2A 3400/4885POLB 508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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