SCHEMBL32688145

SCHEMBL32688145

N#Cc1c(SCc2nnn[nH]2)[nH]c(=O)c(Cl)c1-c1cccc(C(=O)O)c1

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ ACMSD Q8TDX5 13/20 0.44
▸ ADORA1 P30542 2/20 0.39
▸ MEN1 O00255 2/20 0.37
▸ POLB P06746 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ HSD11B1 P28845 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688070 0.93 ACMSD (0.47) ACMSDADORA1MEN1POLBKMT2A
SCHEMBL32688374 0.89 NPC1 (0.40) ACMSDADORA1MEN1POLBKMT2A
SCHEMBL32688035 0.89 MEN1 (0.41) ACMSDMEN1POLBKMT2AHSD11B1
SCHEMBL32688098 0.88 ACMSD (0.45) ACMSDMEN1POLBKMT2A
SCHEMBL32688247 0.84 ACMSD (0.44) ACMSDADORA1KMT2A
SCHEMBL32687972 0.83 HSD11B1 (0.38) MEN1POLBKMT2AHSD11B1
SCHEMBL32688180 0.82 POLB (0.49) ACMSDADORA1MEN1POLBKMT2A
SCHEMBL32688478 0.82 ALDH1A1 (0.41) ACMSDADORA1MEN1POLBKMT2A
SCHEMBL32688370 0.81 POLB (0.41) ACMSDMEN1POLBKMT2AHSD11B1
SCHEMBL20340177 0.81 ACMSD (0.60) ACMSDADORA1MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK ACMSD 142/4885ADORA1 1595/4885MEN1 4353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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