Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3270325 | 0.87 | KDM4E (0.35) | HPGD | |
| SCHEMBL3272702 | 0.87 | PDE7A (0.39) | MAPK1SMN1; SMN2HPGD | |
| SCHEMBL3269317 | 0.86 | MEN1 (0.36) | MAPK8HPGD | |
| SCHEMBL3267800 | 0.84 | TUBB4A (0.42) | MAPK8 | |
| SCHEMBL3270253 | 0.84 | TUBB4A (0.31) | SMN1; SMN2MAPK8 | |
| SCHEMBL3268931 | 0.83 | TUBB4A (0.37) | HPGD | |
| SCHEMBL3173375 | 0.82 | SMN1; SMN2 (0.40) | NPC1TP53ALOX15MAPK1RAB9A | |
| SCHEMBL3268818 | 0.82 | USP7 (0.36) | RAB9A | |
| SCHEMBL3270359 | 0.80 | MMP1 (0.33) | HPGD | |
| SCHEMBL3269989 | 0.80 | KDR (0.39) | TP53MAPK8GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |