Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | TUBB | P07437 | 1/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3269545 | 0.87 | TYMS (0.35) | KDRTYMSMAPK8PARP1FEN1 | |
| SCHEMBL3268577 | 0.87 | KDR (0.39) | KDRMAPK8GCKPARP1MAPT | |
| SCHEMBL3268931 | 0.86 | TUBB4A (0.37) | KDRPOLBMEN1KMT2ATUBB4A | |
| SCHEMBL3275434 | 0.85 | EDNRA (0.43) | KDRMAPK8PARP1MAPTMEN1 | |
| SCHEMBL3269135 | 0.84 | RHEB (0.43) | EPHX1MAPK8FEN1MEN1KMT2A | |
| SCHEMBL3168153 | 0.83 | PTGS2 (0.41) | KDRTYMSEPHX1MAPK8GCK | |
| SCHEMBL3269102 | 0.81 | PDPK1 (0.36) | TYMSPARP1MAPTPOLBMEN1 | |
| SCHEMBL3839280 | 0.81 | TUBB4A (0.44) | TYMSEPHX1SLC6A9MAPTPOLB | |
| SCHEMBL3268889 | 0.81 | MAPK8 (0.32) | MAPK8PARP1MAPT | |
| SCHEMBL3270806 | 0.81 | TYMS (0.39) | KDRTYMSEPHX1MAPK8SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |