Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268936 | 0.87 | NPC1 (0.38) | HPGD | |
| SCHEMBL3272702 | 0.86 | PDE7A (0.39) | KDM4ELMNAMAPTGAAALDH1A1 | |
| SCHEMBL3269317 | 0.85 | MEN1 (0.36) | HPGD | |
| SCHEMBL3270253 | 0.83 | TUBB4A (0.31) | LMNA | |
| SCHEMBL3267800 | 0.83 | TUBB4A (0.42) | KDM4EMAPTNPSR1 | |
| SCHEMBL3184621 | 0.82 | PARP1 (0.35) | KDM4ELMNAMAPTNPSR1GAA | |
| SCHEMBL3268931 | 0.82 | TUBB4A (0.37) | NPSR1ALDH1A1HPGD | |
| SCHEMBL3268818 | 0.81 | USP7 (0.36) | NPSR1PTPN11 | |
| SCHEMBL3270359 | 0.79 | MMP1 (0.33) | HPGD | |
| SCHEMBL4038003 | 0.78 | PARP1 (0.39) | KDM4ELMNAMAPTNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |