Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22628079 | 0.94 | SENP2 (0.44) | THRBLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL32689691 | 0.94 | SENP2 (0.44) | THRBLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL22628167 | 0.92 | MAPT (0.38) | THRBLMNAKMT2AALDH1A1MAPT | |
| SCHEMBL32689700 | 0.89 | ATF4 (0.36) | KMT2AALDH1A1HPGDRAB9A | |
| SCHEMBL22627874 | 0.89 | ATF4 (0.36) | KMT2AALDH1A1HPGDRAB9A | |
| SCHEMBL22628024 | 0.89 | ATF4 (0.37) | LMNAKMT2AMEN1ALDH1A1ALOX15 | |
| SCHEMBL22437035 | 0.89 | ATF4 (0.37) | THRBALDH1A1MAPTHPGDSENP2 | |
| SCHEMBL19556219 | 0.89 | ATF4 (0.37) | THRBALDH1A1MAPTHPGDSENP2 | |
| SCHEMBL22628519 | 0.88 | ATF4 (0.47) | MAPTSENP2SENP1RAB9A | |
| SCHEMBL19555951 | 0.87 | ATF4 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-25 | — | — | EP | disclosed |