Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268577 | 0.87 | KDR (0.39) | MAPK8PARP1KDR | |
| SCHEMBL3269989 | 0.87 | KDR (0.39) | TYMSMAPK8POLBPARP1KDR | |
| SCHEMBL3268931 | 0.86 | TUBB4A (0.37) | POLBKDRMEN1KMT2A | |
| SCHEMBL3275434 | 0.85 | EDNRA (0.43) | MAPK8PARP1KDRMEN1KMT2A | |
| SCHEMBL3268815 | 0.83 | TNKS2 (0.38) | TYMSMAPK8POLBPARP1MEN1 | |
| SCHEMBL3175305 | 0.83 | TYMS (0.37) | TYMSMAPK8POLBPARP1KDR | |
| SCHEMBL3269135 | 0.82 | RHEB (0.43) | MAPK8FEN1MEN1KMT2A | |
| SCHEMBL3268889 | 0.81 | MAPK8 (0.32) | MAPK8PARP1 | |
| SCHEMBL3269102 | 0.81 | PDPK1 (0.36) | TYMSPOLBPARP1MEN1KMT2A | |
| SCHEMBL3268326 | 0.79 | CCNC (0.33) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |