Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL326680 | 0.85 | MCHR1 (0.49) | MCHR1KCNH2HRH3 | |
| SCHEMBL327554 | 0.79 | MCHR1 (0.77) | MCHR1KCNH2HRH3 | |
| SCHEMBL326280 | 0.76 | MCHR1 (0.41) | MCHR1KCNH2HRH3 | |
| SCHEMBL321035 | 0.70 | MCHR1 (0.79) | MCHR1KCNH2HRH3 | |
| SCHEMBL322039 | 0.68 | MCHR1 (0.78) | MCHR1KCNH2HRH3 | |
| SCHEMBL19832548 | 0.68 | SIGMAR1 (0.61) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL322018 | 0.68 | MCHR1 (0.82) | MCHR1KCNH2HRH3 | |
| SCHEMBL326893 | 0.67 | MCHR1 (0.63) | MCHR1KCNH2KDM4EALDH1A1MEN1 | |
| SCHEMBL325939 | 0.67 | MCHR1 (0.48) | MCHR1KCNH2 | |
| SCHEMBL16161559 | 0.65 | ALDH1A1 (0.43) | MCHR1KCNH2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590969-A2 | THERAPEUTIC AGENTS 976 | AstraZeneca AB (SE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004588-A2 | THERAPEUTIC AGENTS 976 | ASTRAZENECA AB (SE) | 2012-01-12 | — | — | WO | disclosed |