Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trichloroacetic Acid SCHEMBL11182990 | 0.89 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNARAB9AKMT2A | |
| SCHEMBL27780 | 0.84 | — | — | |
| Ammonia Solution, Strong SCHEMBL1579773 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNARAB9AKMT2A | |
| SCHEMBL20656243 | 0.76 | SCN9A (0.40) | ALDH1A1KDM4ELMNARAB9AKMT2A | |
| SCHEMBL9348603 | 0.74 | RAB9A (0.42) | ALDH1A1KDM4ELMNARAB9AKMT2A | |
| SCHEMBL1446364 | 0.73 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNARAB9AKMT2A | |
| SCHEMBL1446337 | 0.73 | SMN1; SMN2 (0.46) | ALDH1A1KDM4ELMNAPOLBCYP1A2 | |
| SCHEMBL2034646 | 0.73 | — | — | |
| SCHEMBL8406068 | 0.73 | ALOX15 (0.48) | ALDH1A1KDM4EPOLBCYP1A2CYP3A4 | |
| SCHEMBL11507005 | 0.72 | ALDH1A1 (0.39) | ALDH1A1KDM4ELMNARAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087396-A1 | Novel Compounds Having Selective Inhibiting Effect at GSK3 | BERG STEFAN | 2010-04-08 | — | — | US | disclosed |
| US-7595321-B2 | Compounds having selective inhibiting effect at GSK3 | ASTRAZENECA AB (SE) | 2009-09-29 | — | — | US | disclosed |
| CN-100360522-C | Novel compounds having selective inhibiting effect at GSK3 | ASTRAZENECA AB (SE) | 2008-01-09 | — | — | CN | disclosed |
| EP-1575942-B1 | COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| US-20060116385-A1 | Novel compounds having selective inhibiting effect at gsk3 | ASTRAZENECA AB (SE) | 2006-06-01 | — | — | US | disclosed |
| CN-1726210-A | Novel compounds having selective inhibiting effect at GSK3 | ASTRAZENECA AB (SE) | 2006-01-25 | — | — | CN | disclosed |
| EP-1575942-A1 | NOVEL COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004055009-A1 | NOVEL COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087396-A1 | Novel Compounds Having Selective Inhibiting Effect at GSK3 | GSK3B, GSK3A, NR5A2 | ALDH1A1 4583/4885KDM4E 1330/4885LMNA 1801/4885 |
| US-20060116385-A1 | Novel compounds having selective inhibiting effect at gsk3 | GSK3B, GSK3A, NR5A2 | ALDH1A1 4529/4885KDM4E 1106/4885LMNA 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.