Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28224986 | 0.86 | KCNA5 (0.47) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL477395 | 0.83 | KCNA5 (0.61) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL9285273 | 0.81 | KCNA5 (0.59) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL21480329 | 0.81 | KCNA5 (0.59) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL3288789 | 0.81 | DPP4 (0.62) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL1130345 | 0.81 | KCNA5 (0.59) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL27383308 | 0.81 | ATM (0.45) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| SCHEMBL5018831 | 0.81 | KCNA5 (0.68) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL2456280 | 0.80 | DPP4 (0.60) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL14856550 | 0.80 | KCNA5 (0.58) | KCNA5KCNH2CYP2A6ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399674-B2 | Quinolines | HOFFMAN-LA ROCHE INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120136018-A1 | QUINOLINES | KOLCZEWSKI SABINE (DE) | 2012-05-31 | — | — | US | disclosed |
| EP-2195296-A1 | QUINOLINE DERIVATIVES AS 5HT5A RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-06-16 | — | — | EP | disclosed |
| US-20090088451-A1 | QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | US | disclosed |
| WO-2009040290-A1 | QUINOLINE DERIVATIVES AS 5HT5A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088451-A1 | QUINOLINES | HTR5A, HTR1A, HTR1E | KCNA5 216/4885KCNH2 524/4885CYP2A6 471/4885 |
| US-20120136018-A1 | QUINOLINES | HTR5A, HTR1A, HTR1E | KCNA5 216/4885KCNH2 524/4885CYP2A6 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.