Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276583 | 0.83 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL3276517 | 0.76 | NPC1 (0.51) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL1012499 | 0.74 | HDAC3 (0.78) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL8252106 | 0.73 | HDAC1 (1.00) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL3275324 | 0.73 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| Ethylene SCHEMBL8378455 | 0.71 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL3274890 | 0.70 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL13504050 | 0.69 | HPGD (0.66) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL3275748 | 0.69 | NPC1 (0.49) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL10361230 | 0.69 | KCNA3 (0.62) | RAB9ANPC1SMN1; SMN2HPGDHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | VTVX HOLDINGS II LLC | 2010-04-08 | — | — | US | claimed |
| US-8383683-B2 | Pharmaceutical use of substituted amides | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383683-B2 | Pharmaceutical use of substituted amides | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383683-B2 | Pharmaceutical use of substituted amides | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | VTVX HOLDINGS II LLC | 2010-04-08 | — | — | US | disclosed |
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | VTVX HOLDINGS II LLC | 2010-04-08 | — | — | US | disclosed |
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | VTVX HOLDINGS II LLC | 2010-04-08 | — | — | US | disclosed |
| WO-2008134221-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | HSD11B1, HSD17B1, HSD11B2 | RAB9A 4157/4885NPC1 1542/4885SMN1; SMN2 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.