Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274589 | 1.00 | NR1H2 (0.42) | NR1H2NR1H3SLC6A9DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL3273139 | 0.99 | NR1H2 (0.42) | NR1H2NR1H3SLC6A9DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL3273145 | 0.99 | NR1H2 (0.42) | NR1H2NR1H3SLC6A9DRD4DRD2 | |
| SCHEMBL3273816 | 0.82 | DRD2 (0.38) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3273813 | 0.82 | DRD2 (0.38) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3273550 | 0.81 | DRD1 (0.37) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3273557 | 0.81 | DRD1 (0.37) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3274271 | 0.81 | SIGMAR1 (0.50) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3274274 | 0.81 | SIGMAR1 (0.50) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3273936 | 0.80 | SIGMAR1 (0.49) | DRD4DRD2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273883-B2 | Method for producing optically active 2-arylpiperazine derivative | KANEKA CORPORATION (JP) | 2012-09-25 | — | — | US | disclosed |
| US-20100087643-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERAZINE DERIVATIVE | KANEKA CORPORATION (JP) | 2010-04-08 | — | — | US | disclosed |
| EP-2119709-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERAZINE DERIVATIVE | Kaneka Corporation (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087643-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERAZINE DERIVATIVE | CYP2W1, AGPS, DHPS | NR1H2 3565/4885NR1H3 4318/4885SLC6A9 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.