Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25245135 | 0.79 | LMNA (0.44) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 | |
| SCHEMBL15169039 | 0.77 | LMNA (0.49) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 | |
| SCHEMBL324352 | 0.76 | ALDH1A1 (0.64) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 | |
| SCHEMBL2090301 | 0.75 | ALDH1A1 (0.47) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 | |
| SCHEMBL15167749 | 0.73 | SIGMAR1 (0.42) | LMNAL3MBTL1ALDH1A1NPSR1KCNH2 | |
| SCHEMBL15167746 | 0.73 | SIGMAR1 (0.42) | LMNAL3MBTL1ALDH1A1NPSR1KCNH2 | |
| SCHEMBL15169147 | 0.73 | PRMT1 (0.51) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 | |
| SCHEMBL2090299 | 0.72 | PKM (0.49) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 | |
| SCHEMBL25236543 | 0.72 | LMNA (0.57) | LMNAMAPT | |
| Hydrochloric Acid SCHEMBL16192657 | 0.72 | PRMT1 (0.50) | LMNAL3MBTL1ALDH1A1NPSR1PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590953-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004604-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2012-01-12 | — | — | WO | disclosed |