Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.58 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.58 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.58 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278646 | 0.89 | SLC6A7 (0.74) | SLC6A7GAAMAPTALOX15ALOX12 | |
| SCHEMBL1711060 | 0.86 | MEN1 (0.71) | SLC6A7GAAMAPTALOX15ALOX12 | |
| SCHEMBL3275688 | 0.86 | MAPK8 (0.60) | SLC6A7GAAMAPTALOX15ALOX12 | |
| SCHEMBL1711137 | 0.85 | LMNA (0.64) | NAMPTSLC6A7GAAMAPTALOX15 | |
| SCHEMBL3265941 | 0.85 | RAB9A (0.70) | SLC6A7GAAMAPTALOX15ALOX12 | |
| SCHEMBL20394947 | 0.83 | CA1 (0.63) | SLC6A7GAAMAPTALOX15ALOX12 | |
| SCHEMBL1711371 | 0.83 | NAMPT (0.60) | NAMPTSLC6A7GAAMAPTALOX15 | |
| SCHEMBL1730403 | 0.83 | KMT2A (0.68) | NAMPTSLC6A7GAAMAPTALOX15 | |
| SCHEMBL1710860 | 0.82 | SLC6A7 (0.57) | SLC6A7GAAMAPTALOX15ALOX12 | |
| SCHEMBL1177142 | 0.81 | EPHX2 (0.72) | MAPK10PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | disclosed |
| US-8258138-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2012-09-04 | — | — | US | disclosed |
| US-20100087437-A1 | Novel Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087437-A1 | Novel Potassium Channel Blockers | KCNB1, KCNJ2, KCNJ11 | NAMPT 2705/4885SLC6A7 581/4885GAA 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.