Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8465598 | 0.84 | NPC1 (0.33) | NISCHNPC1RAB9ALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3275125 | 0.80 | CA12 (0.35) | NISCHNPC1RAB9APTGS2LMNA | |
| Hydrochloric Acid SCHEMBL713862 | 0.70 | ESR2 (0.36) | ESR2CYP2A6CYP2B6NISCHNPC1 | |
| Hydrochloric Acid SCHEMBL10318028 | 0.69 | PTGS2 (0.37) | CYP2A6CYP2B6NISCHPTGS2PDCD1 | |
| Hydrochloric Acid SCHEMBL27629774 | 0.69 | ESR2 (0.41) | ESR2CYP2A6CYP2B6NISCHNPC1 | |
| SCHEMBL27620844 | 0.69 | ALDH1A1 (0.50) | CYP2A6CYP2B6NISCHPTGS2PDCD1 | |
| Hydrochloric Acid SCHEMBL4444061 | 0.68 | ESR2 (0.40) | ESR2CYP2A6CYP2B6NISCHNPC1 | |
| Hydrochloric Acid SCHEMBL20485163 | 0.67 | ESR2 (0.36) | ESR2CYP2A6CYP2B6NPC1RAB9A | |
| SCHEMBL4830408 | 0.66 | ESR2 (0.60) | ESR2CYP2A6CYP2B6PDCD1CD274 | |
| SCHEMBL1476609 | 0.66 | ALDH1A1 (0.58) | CYP2A6NISCHPTGS2PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2930209-B2 | FIBER-REINFORCED POLYPROPYLENE RESIN COMPOSITION AND MOLDED ARTICLE OF SAME | JAPAN POLYPROPYLENE CORP (JP) | 2022-07-13 | — | — | EP | disclosed |
| EP-2930209-B1 | FIBER-REINFORCED POLYPROPYLENE RESIN COMPOSITION AND MOLDED ARTICLE OF SAME | JAPAN POLYPROPYLENE CORP (JP) | 2018-01-31 | — | — | EP | disclosed |
| US-20150315365-A1 | FIBER-REINFORCED POLYPROPYLENE RESIN COMPOSITION AND MOLDED ARTICLE OF SAME | JAPAN POLYPROPYLENE CORPORATION (JP) | 2015-11-05 | — | — | US | disclosed |
| EP-2930209-A1 | FIBER-REINFORCED POLYPROPYLENE RESIN COMPOSITION AND MOLDED ARTICLE OF SAME | Japan Polypropylene Corporation (JP) | 2015-10-14 | — | — | EP | disclosed |
| EP-1717270-B1 | Polypropylene based heat shrinkable film | JAPAN POLYPROPYLENE CORP (JP) | 2010-06-30 | — | — | EP | disclosed |
| US-7662888-B2 | Polypropylene based heat shrinkable film | JAPAN POLYPROPYLENE CORPORATION (JP) | 2010-02-16 | — | — | US | disclosed |
| US-7390575-B2 | Propylene-ethylene random block copolymer and biaxially oriented multi-layer film using the same as a surface layer | JAPAN POLYPROPYLENE CORPORATION (JP) | 2008-06-24 | — | — | US | disclosed |
| US-20060246308-A1 | Polypropylene based heat shrinkable film | JAPAN POLYPROPYLENE CORPORATION (JP) | 2006-11-02 | — | — | US | disclosed |
| EP-1717270-A1 | Polypropylene based heat shrinkable film | Japan Polypropylene Corporation (JP) | 2006-11-02 | — | — | EP | disclosed |
| EP-1588843-B1 | Biaxially oriented multilayer film comprising a surface layer based on a propylene-ethylene random block copolymer | JAPAN POLYPROPYLENE CORP (JP) | 2006-09-27 | — | — | EP | disclosed |
| EP-1588843-A1 | Biaxially oriented multilayer film comprising a surface layer based on a propylene-ethylene random block copolymer | Japan Polypropylene Corporation (JP) | 2005-10-26 | — | — | EP | disclosed |
| US-20050113517-A1 | Propylene-ethylene random block copolymer and biaxially oriented multi-layer film using the same as a surface layer | JAPAN POLYPROPYLENE CORPORATION (JP) | 2005-05-26 | — | — | US | disclosed |
| US-5942459-A | ALUMOXANE-FREE MIXTURE OF TRANSITION METAL METALLOCENE, ORGANOALUMINUM COMPOUND, BORIC ACID-CONTAINING POWDER | MITSUBISHI CHEMICAL CORPORATION (JP) | 1999-08-24 | — | — | US | disclosed |
| EP-0728773-B1 | Catalysts for olefin polymerization and a process for preparing olefin polymers therewith | MITSUBISHI CHEM CORP (JP) | 1998-11-04 | — | — | EP | disclosed |
| EP-0728773-A1 | Catalysts for olefin polymerization and a process for preparing olefin polymers therewith | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-08-28 | — | — | EP | disclosed |