Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027803 | 0.86 | MGAM (0.46) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL7424494 | 0.86 | ALDH1A1 (0.49) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL5655219 | 0.83 | ALDH1A1 (0.47) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL12416491 | 0.83 | ALDH1A1 (0.47) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL12197531 | 0.81 | MGAM (0.45) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL15775618 | 0.81 | MGAM (0.45) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4781030 | 0.80 | MGAM (0.56) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL21281624 | 0.80 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15775617 | 0.80 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL17193769 | 0.80 | ALDH1A1 (0.45) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692030-B2 | Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer | UNIVERSITY OF WASHINGTON (US) | 2010-04-06 | — | — | US | disclosed |
| US-20080103192-A1 | CONJUGATES OF ARTEMISININ-RELATED ENDOPEROXIDES AND HYDRAZONE DERIVATIVES FOR THE TREATMENT OF CANCER | WASHINGTON, UNIVERSITY OF (US) | 2008-05-01 | — | — | US | disclosed |
| WO-2008046109-A2 | CONJUGATES OF ARTEMISININ-RELATED ENDOPEROXIDES AND HYDRAZONE DERIVATIVES FOR THE TREATMENT OF CANCER | UNIVERSITY OF WASHINGTON (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103192-A1 | CONJUGATES OF ARTEMISININ-RELATED ENDOPEROXIDES AND HYDRAZONE DERIVATIVES FOR THE TREATMENT OF CANCER | DHPS, GPX4, DHFR | MGAM 4724/4885GAA 2023/4885SI 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.