SCHEMBL327615

SCHEMBL327615

CCC(=O)N1CCC(O)(O)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
OPRM1 P35372 1/20 0.46
BLM P54132 1/20 0.43
CHRNB2 P17787 3/20 0.41
CHRNA3 P32297 3/20 0.41
CHRNA4 P43681 3/20 0.41
CHRNB3 Q05901 1/20 0.41
CHRNA6 Q15825 1/20 0.41
EPHX2 P34913 3/20 0.41
CHRNB4 P30926 2/20 0.39
CHRNA7 P36544 2/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 2/20 0.38
KDM4E B2RXH2 1/20 0.38
USP2 O75604 1/20 0.38
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14277668 0.84 ALDH1A1 (0.50) ALDH1A1OPRM1BLMCHRNB2CHRNA3
SCHEMBL16181352 0.83 L3MBTL1 (0.47) ALDH1A1OPRM1CHRNB2CHRNA3CHRNA4
SCHEMBL15998851 0.82 ALDH1A1 (0.47) ALDH1A1OPRM1BLMCHRNB2CHRNA3
SCHEMBL13360768 0.82 ALDH1A1 (0.52) ALDH1A1OPRM1BLMCHRNB2CHRNA3
SCHEMBL16887629 0.81 OPRM1 (0.42) ALDH1A1OPRM1BLMCHRNB2CHRNA3
SCHEMBL10074073 0.80 ALDH1A1 (0.45) ALDH1A1OPRM1BLMCHRNB2CHRNA3
SCHEMBL180620 0.80
SCHEMBL20756575 0.80 BLM (0.57) ALDH1A1BLMCHRNB2CHRNA3CHRNA4
SCHEMBL2739418 0.80 BLM (0.57) ALDH1A1BLMCHRNB2CHRNA3CHRNA4
SCHEMBL13804168 0.78 ALDH1A1 (0.48) ALDH1A1OPRM1BLMCHRNB2CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210023186-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2021-01-28 US disclosed
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS 2017-07-13 US disclosed
US-9636412-B2 Conjugates of an anti-TNF-alpha antibody NEKTAR THERAPEUTICS (US) 2017-05-02 US disclosed
US-20170035896-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS 2017-02-09 US disclosed
US-20160175402-A1 POLYMER-FACTOR VIII MOIETY CONJUGATES NEKTAR THERAPEUTICS 2016-06-23 US disclosed
US-9347054-B2 Polymer factor IX moiety conjugates NEKTAR THERAPEUTICS (US) 2016-05-24 US disclosed
US-20160030587-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS 2016-02-04 US disclosed
US-20150038422-A1 UNIT DOSAGE FORMS OF PHARMACEUTICAL COMPOSITIONS COMPRISING A POLYMER-FACTOR VIII POLYPEPTIDE CONJUGATE NEKTAR THERAPEUTICS 2015-02-05 US disclosed
US-8889831-B2 Unit dosage forms of pharmaceutical compositions comprising a polymer-factor VIII polypeptide conjugate NEKTAR THERAPEUTICS (US) 2014-11-18 US disclosed
US-20140328791-A1 Conjugates of an IL-2 Moiety and a Polymer NEKTAR THERAPEUTICS 2014-11-06 US disclosed
US-20100130684-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-27 US disclosed
US-20100125049-A1 POLYMER FACTOR VIII MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-20 US disclosed
US-20100120689-A1 POLYMER FACTOR VIII MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-13 US disclosed
US-20100120982-A1 POLYMER-FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-13 US disclosed
US-7714114-B2 Conjugates of an EPO moiety and a polymer NEKTAR THERAPEUTICS (US) 2010-05-11 US disclosed
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS (US) 2010-01-28 US disclosed
US-20090280550-A1 Polymer-Factor IX Moiety Conjugates NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-11-12 US disclosed
US-20090041714-A1 Binding element comprising polyethylene glycol and antihemophilic factor for use in treatment of hemophilia NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-02-12 US disclosed
US-20080058504-A1 Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor NEKTAR THERAPEUTICS 2008-03-06 US disclosed
US-7199223-B2 Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor NEKTAR THERAPEUTICS AL, CORPORATION (US) 2007-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150038422-A1 UNIT DOSAGE FORMS OF PHARMACEUTICAL COMPOSITIONS COMPRISING A POLYMER-FACTOR VIII POLYPEPTIDE CONJUGATE F8, F13B, F13A1 ALDH1A1 3099/4885OPRM1 1815/4885BLM 523/4885
US-20090041714-A1 Binding element comprising polyethylene glycol and antihemophilic factor for use in treatment of hemophilia F13B, F8, F13A1 ALDH1A1 3597/4885OPRM1 2458/4885BLM 2637/4885
US-20140328791-A1 Conjugates of an IL-2 Moiety and a Polymer IL2, IL2RA, ILF2 ALDH1A1 2509/4885OPRM1 2993/4885BLM 2970/4885
US-20100120689-A1 POLYMER FACTOR VIII MOIETY CONJUGATES F8, F9, F13B ALDH1A1 2770/4885OPRM1 3681/4885BLM 538/4885
US-20170035896-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 ALDH1A1 3118/4885OPRM1 3101/4885BLM 1229/4885
US-20100120982-A1 POLYMER-FACTOR IX MOIETY CONJUGATES F9, F13A1, F13B ALDH1A1 2876/4885OPRM1 3142/4885BLM 1267/4885
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 ALDH1A1 2494/4885OPRM1 1886/4885BLM 3468/4885
US-20100125049-A1 POLYMER FACTOR VIII MOIETY CONJUGATES F8, F9, F13B ALDH1A1 2770/4885OPRM1 3681/4885BLM 538/4885
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 ALDH1A1 2449/4885OPRM1 1855/4885BLM 3656/4885
US-20100130684-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 ALDH1A1 3118/4885OPRM1 3101/4885BLM 1229/4885
US-20160030587-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 ALDH1A1 2494/4885OPRM1 1886/4885BLM 3468/4885
US-20160175402-A1 POLYMER-FACTOR VIII MOIETY CONJUGATES F8, F9, F13B ALDH1A1 2572/4885OPRM1 3711/4885BLM 489/4885
US-20080058504-A1 Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor F8, F13A1, F13B ALDH1A1 2393/4885OPRM1 194/4885BLM 1443/4885
US-20210023186-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 ALDH1A1 3118/4885OPRM1 3101/4885BLM 1229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.