Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 19/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | NT5E | P21589 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrobetulonic Acid SCHEMBL10061167 | 1.00 | GPBAR1 (0.71) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| Dihydrobetulonic Acid SCHEMBL13908784 | 1.00 | GPBAR1 (0.71) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| Dihydrobetulonic Acid SCHEMBL14414141 | 1.00 | GPBAR1 (0.71) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| SCHEMBL10061168 | 0.91 | GPBAR1 (0.59) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| SCHEMBL16511700 | 0.91 | GPBAR1 (0.59) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| SCHEMBL13956965 | 0.90 | GPBAR1 (0.69) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| Methyl Dihydrobetulonate SCHEMBL13747683 | 0.89 | GPBAR1 (0.58) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| SCHEMBL13301977 | 0.89 | GPBAR1 (0.65) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| SCHEMBL9891261 | 0.89 | GPBAR1 (0.57) | GPBAR1LMNANT5ESMN1; SMN2PRKCD | |
| SCHEMBL14134447 | 0.89 | GPBAR1 (0.65) | GPBAR1LMNANT5ESMN1; SMN2PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303058-B2 | Betulonic and betulinic acid derivatives | Leunis, Jean-Claude (BE) | 2016-04-05 | — | — | US | disclosed |
| EP-1999139-B1 | BETULONIC ACID ESTERS AND BETULINIC ACID POLYALKYLENE-GLYCOL DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTION AND CANCER | LEUNIS JEAN-CLAUDE (BE) | 2014-08-20 | — | — | EP | disclosed |
| US-20140066416-A1 | BETULONIC AND BETULINIC ACID DERIVATIVES | Leunis, Jean-Claude (BE) | 2014-03-06 | — | — | US | disclosed |
| US-8586569-B2 | Betulonic and betulinic acid derivatives | Leunis, Jean-Claude (BE) | 2013-11-19 | — | — | US | disclosed |
| WO-2011153319-A1 | C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-08 | — | — | WO | disclosed |
| US-20100087539-A1 | N'--3-AMINO-3-PHENYLPROPEONIC ACID AND THE PHARMACEUTICALLY ACCEPTABLE DERIVATIVES THEREOF, A METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A MEDICINAL AGENT | INSTITUT NEFTEKHIMII I KATALIZA ROSSIISKOI AKADEMII NAUK (RU) | 2010-04-08 | — | — | US | disclosed |
| EP-2088152-A1 | N'-{N-[3-OXO-LUPEN-28-OYL]-9-AMINONONANOYL}-3-AMINO-3-PHENYLPROPEONIC ACID AND THE PHARMACEUTICALLY ACCEPTABLE DERIVATIVES THEREOF, A METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A MEDICINAL AGENT | Institut Neftekhimii I Kataliza Rossiiskoi Akademii Nauk (RU) | 2009-08-12 | — | — | EP | disclosed |
| US-20090068257-A1 | BETULONIC AND BETULINIC ACID DERIVATIVES | JEAN-CLAUDE LEUNIS (BE) | 2009-03-12 | — | — | US | disclosed |
| EP-1999139-A2 | BETULONIC ACID ESTERS AND BETULINIC ACID POLYALKYLENE-GLYCOL DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTION AND CANCER | SNDV sprl (BE) | 2008-12-10 | — | — | EP | disclosed |
| US-20070232577-A1 | Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin | ADVANCED LIFE SCIENCES, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| US-20070232577-A1 | Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin | ADVANCED LIFE SCIENCES, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| WO-2007112043-A2 | SYNTHETIC PENTACYCLIC TRITERPENOIDS AND DERIVATIVES OF BETULINIC ACID AND BETULIN | ADVANCED LIFE SCIENCES INC. (US) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007101873-A2 | BETULONIC ACID ESTERS AND BETULINIC ACID POLYALKYLENE-GLYCOL DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTION AND CANCER | SNDV SPRL (BE) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232577-A1 | Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin | BET1, PGGT1B, BRCA1 | GPBAR1 225/4885LMNA 4313/4885NT5E 3553/4885 |
| US-20090068257-A1 | BETULONIC AND BETULINIC ACID DERIVATIVES | BET1, PGGT1B, PAG1 | GPBAR1 100/4885LMNA 3136/4885NT5E 3765/4885 |
| US-20140066416-A1 | BETULONIC AND BETULINIC ACID DERIVATIVES | BET1, BCAT1, PGGT1B | GPBAR1 90/4885LMNA 3280/4885NT5E 3081/4885 |
| US-20100087539-A1 | N'--3-AMINO-3-PHENYLPROPEONIC ACID AND THE PHARMACEUTICALLY ACCEPTABLE DERIVATIVES THEREOF, A METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A MEDICINAL AGENT | GART, DNPEP, IL4I1 | GPBAR1 516/4885LMNA 2743/4885NT5E 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.