Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.56 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27626620 | 0.87 | MTNR1A (0.60) | MTNR1AMTNR1BIDH1SIGMAR1NQO2 | |
| SCHEMBL28193568 | 0.86 | HTR2A (0.63) | MTNR1AMTNR1BNQO2 | |
| 1,4-Dimethoxybenzene SCHEMBL11332999 | 0.84 | L3MBTL1 (0.59) | CYP1A2 | |
| SCHEMBL9971034 | 0.84 | MTNR1A (0.61) | MTNR1AMTNR1BIDH1CYP1A2CYP2A6 | |
| SCHEMBL3275120 | 0.83 | MTNR1A (0.44) | MTNR1AMTNR1BIDH1NQO2 | |
| SCHEMBL1012628 | 0.83 | MTNR1A (0.56) | MTNR1AMTNR1BIDH1CYP1A2CYP2A6 | |
| SCHEMBL6856603 | 0.83 | MTNR1A (0.59) | MTNR1AMTNR1BIDH1CYP1A2CYP2A6 | |
| SCHEMBL7295488 | 0.83 | MTNR1A (0.56) | MTNR1AMTNR1BIDH1CYP1A2CYP2A6 | |
| SCHEMBL15345391 | 0.83 | MTNR1A (0.56) | MTNR1AMTNR1BIDH1CYP1A2CYP2A6 | |
| Bromide SCHEMBL29233693 | 0.81 | MTNR1A (0.55) | MTNR1AMTNR1BIDH1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966134-B1 | NOVEL FUSED PYRROLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-7696240-B2 | Fused pyrrole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-13 | — | — | US | disclosed |
| EP-1966134-A1 | NOVEL FUSED PYRROLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068621-A1 | NOVEL FUSED PYRROLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-21 | — | — | WO | disclosed |
| US-20070142452-A1 | Fused pyrrole derivatives | HOFFMANN-LA ROCHE INC. | 2007-06-21 | — | — | US | disclosed |
| US-6794384-B1 | Hydroxylation activated drug release | DE MONTFORT UNIVERSITY (GB) | 2004-09-21 | — | — | US | disclosed |
| EP-1069915-B1 | HYDROXYLATION ACTIVATED DRUG RELEASE | UNIV MONTFORT (GB) | 2003-06-25 | — | — | EP | disclosed |
| EP-1069915-A2 | HYDROXYLATION ACTIVATED DRUG RELEASE | DE MONTFORT UNIVERSITY (GB) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999040944-A2 | HYDROXYLATION ACTIVATED DRUG RELEASE | DE MONTFORT UNIVERSITY (GB) | 1999-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142452-A1 | Fused pyrrole derivatives | CMA1, PREP, CPA3 | MTNR1A 147/4885MTNR1B 259/4885IDH1 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.