Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR5A | P47898 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573228 | 0.89 | GAA (0.61) | HTR7ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL282589 | 0.84 | ALDH1A1 (0.62) | HTR7SIRT6ALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL29257906 | 0.79 | HTR7 (0.52) | HTR7HTR1AADRB1SIRT6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29876869 | 0.79 | HTR7 (0.52) | HTR7HTR1AADRB1SIRT6ALDH1A1 | |
| SCHEMBL29793662 | 0.79 | ALDH1A1 (0.65) | HTR7ADRB1SIRT6ALDH1A1SMN1; SMN2 | |
| SCHEMBL20876774 | 0.79 | GAA (0.72) | HTR7HTR1AADRB1SIRT6ALDH1A1 | |
| SCHEMBL899512 | 0.79 | ALDH1A1 (0.65) | HTR7ADRB1SIRT6ALDH1A1SMN1; SMN2 | |
| SCHEMBL4002581 | 0.77 | ADRB1 (0.58) | HTR7HTR1AADRB1SIRT6ALDH1A1 | |
| SCHEMBL522009 | 0.77 | ALDH1A1 (0.69) | HTR7HTR1AADRB1SIRT6ALDH1A1 | |
| SCHEMBL899660 | 0.77 | ADRB1 (0.58) | HTR7HTR1AHTR6ADRB1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2012-03-14 | — | — | EP | disclosed |