Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | OXER1 | Q8TDS5 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9331256 | 1.00 | AKT1 (0.49) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL9188658 | 0.87 | TSHR (0.63) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL2401509 | 0.87 | TSHR (0.63) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL2401513 | 0.87 | TSHR (0.63) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL9975540 | 0.86 | NR1I2 (0.53) | TSHROXER1ALOX5ALDH1A1MAPT | |
| SCHEMBL16371434 | 0.85 | TSHR (0.50) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL16371432 | 0.85 | TSHR (0.50) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL8799477 | 0.85 | TSHR (0.50) | AKT1TSHROXER1ALOX5ALDH1A1 | |
| SCHEMBL9003288 | 0.85 | ALDH1A1 (0.58) | TSHROXER1ALOX5ALDH1A1LMNA | |
| SCHEMBL4444400 | 0.85 | ALDH1A1 (0.58) | TSHROXER1ALOX5ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822542-B2 | Isoketal scavengers and mitigation of disorders involving oxidative injury | VANDERBILT UNIVERSITY (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120157501-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | VANDERBILT UNIVERSITY | 2012-06-21 | — | — | US | disclosed |
| US-7705054-B1 | Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases | VANDERBILT UNIVERSITY (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705054-B1 | Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases | VANDERBILT UNIVERSITY (US) | 2010-04-27 | — | — | US | disclosed |
| US-4904820-A | Process for substituting a hydrocarbon group | G. D. SEARLE & CO. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4777275-A | CHEMICAL INTERMEDIATE FOR PROSTAGLANDINE | G. D. SEARLE & CO. (US) | 1988-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157501-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | PDXK, KYNU, FN3K | AKT1 1955/4885TSHR 3896/4885OXER1 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.