Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3284873 | 0.96 | L3MBTL3 (0.44) | OPRK1OPRD1MEN1KMT2ADPP8 | |
| SCHEMBL3314682 | 0.90 | OPRK1 (0.42) | OPRK1OPRD1DPP8SMYD3L3MBTL3 | |
| SCHEMBL4718313 | 0.90 | OPRK1 (0.42) | OPRK1OPRD1DPP8SMYD3L3MBTL3 | |
| SCHEMBL3278544 | 0.90 | OPRD1 (0.43) | OPRK1OPRD1MEN1KMT2ADPP8 | |
| SCHEMBL3279496 | 0.90 | DPP8 (0.49) | OPRK1OPRD1DPP8L3MBTL3L3MBTL1 | |
| SCHEMBL3279461 | 0.87 | OPRK1 (0.47) | OPRK1OPRD1SMYD3DPP4HDAC8 | |
| SCHEMBL4717842 | 0.86 | L3MBTL3 (0.41) | OPRK1OPRD1DPP8SMYD3L3MBTL3 | |
| SCHEMBL4722468 | 0.86 | AKT1 (0.43) | OPRK1OPRD1L3MBTL3L3MBTL1CHRM1 | |
| SCHEMBL3278143 | 0.86 | OPRD1 (0.44) | OPRK1OPRD1DPP8SMYD3L3MBTL3 | |
| SCHEMBL3278136 | 0.86 | OPRD1 (0.44) | OPRK1OPRD1DPP8SMYD3L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152171-A1 | CGRP Antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| US-7700589-B2 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-04-20 | — | — | US | disclosed |
| US-20070244099-A1 | CGRP Antagonists | RUDOLF KLAUS | 2007-10-18 | — | — | US | disclosed |
| US-20040132716-A1 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244099-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | OPRK1 6/4885OPRD1 7/4885MEN1 1877/4885 |
| US-20100152171-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | OPRK1 6/4885OPRD1 7/4885MEN1 1877/4885 |
| US-20040132716-A1 | CGRP antagonists | OPRL1, HTR1D, CALCA | OPRK1 10/4885OPRD1 11/4885MEN1 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.