Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054634 | 0.87 | MAPT (0.63) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL654076 | 0.87 | ALDH1A1 (0.55) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL14174537 | 0.86 | ALDH1A1 (0.62) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL3302277 | 0.84 | TDP1 (0.50) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL29560800 | 0.83 | TDP1 (0.49) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL22897851 | 0.83 | TDP1 (0.49) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL22115093 | 0.83 | TSHR (0.51) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL3053127 | 0.79 | HCAR3 (0.49) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL3054662 | 0.79 | VCAM1 (0.51) | TSHRTDP1CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL3051207 | 0.79 | MAPT (0.52) | TSHRTDP1CYP3A4MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714009-B2 | Nitrogen-containing fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |
| US-20070135452-A1 | Nitrogen-containing fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135452-A1 | Nitrogen-containing fused heterocyclic compounds | NPY4R, NR4A3, NR3C2 | TSHR 278/4885TDP1 4581/4885CYP3A4 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.