Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287378 | 0.81 | CTSS (0.56) | TDP1SMN1; SMN2ALDH1A1TSHRKDM4E | |
| SCHEMBL2144250 | 0.80 | CLK4 (0.46) | TDP1SMN1; SMN2ALDH1A1TSHRPDE4A | |
| SCHEMBL13325957 | 0.80 | CTSS (0.54) | TDP1SMN1; SMN2ALDH1A1TSHRKDM4E | |
| SCHEMBL3289094 | 0.78 | ALDH1A1 (0.53) | TDP1SMN1; SMN2ALDH1A1TSHRKDM4E | |
| SCHEMBL3285731 | 0.78 | SMN1; SMN2 (0.50) | TDP1SMN1; SMN2ALDH1A1TSHRKDM4E | |
| SCHEMBL3287056 | 0.77 | TDP1 (0.49) | TDP1SMN1; SMN2ALDH1A1TSHRKDM4E | |
| SCHEMBL13326070 | 0.76 | PDE4A (0.53) | TDP1SMN1; SMN2ALDH1A1PDE4ANPC1 | |
| SCHEMBL3289389 | 0.75 | CTSL (0.68) | TDP1SMN1; SMN2ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL3289275 | 0.75 | CTSS (0.56) | TDP1SMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL13325954 | 0.74 | APP (0.67) | SMN1; SMN2L3MBTL1APPMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1441683-A4 | TRISUBSTITUTED TRIAZINE COMPOUNDS, AND METHODS FOR MAKING AN USING THE COMPOUNDS, WHICH HAVE ANTITUBULIN ACTIVITY | UNIV NEW YORK (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1441683-A2 | TRISUBSTITUTED TRIAZINE COMPOUNDS, AND METHODS FOR MAKING AN USING THE COMPOUNDS, WHICH HAVE ANTITUBULIN ACTIVITY | NEW YORK UNIVERSITY (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20040122009-A1 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2004-06-24 | — | — | US | disclosed |
| WO-2003032903-A2 | TRISUBSTITUTED TRIAZINES COMPOUNDS WITH ANTITUBULIN ACTIVITY | NEW YORK UNIVERSITY (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122009-A1 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | TUBA1C, TUBB1, TUBB | TDP1 718/4885SMN1; SMN2 4365/4885ALDH1A1 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.