Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 6/20 | 0.62 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287838 | 1.00 | SLC9A1 (0.62) | SLC9A1EDNRAHDAC4HTTCYP1A2 | |
| SCHEMBL3655655 | 1.00 | SLC9A1 (0.62) | SLC9A1EDNRAHDAC4HTTCYP1A2 | |
| SCHEMBL3287837 | 1.00 | SLC9A1 (0.62) | SLC9A1EDNRAHDAC4HTTCYP1A2 | |
| SCHEMBL16819920 | 1.00 | SLC9A1 (0.62) | SLC9A1EDNRAHDAC4HTTCYP1A2 | |
| Hydrochloric Acid SCHEMBL11009588 | 0.98 | SLC9A1 (0.60) | SLC9A1EDNRAHDAC4HTTCYP1A2 | |
| SCHEMBL18927360 | 0.88 | SLC9A1 (0.62) | SLC9A1HTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14276417 | 0.84 | SLC9A1 (0.66) | SLC9A1HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL2393407 | 0.84 | SLC9A1 (0.68) | SLC9A1HTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3288310 | 0.84 | SLC9A1 (0.68) | SLC9A1HTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3287377 | 0.84 | SLC9A1 (0.46) | SLC9A1HDAC4HTTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11793821-B2 | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors | MERCK SHARP & DOHME LLC (US) | 2023-10-24 | — | — | US | disclosed |
| CN-109153649-B | Allosteric modulators of nicotinic acetylcholine receptors | 默沙东公司 | 2022-04-19 | — | — | CN | disclosed |
| EP-3433234-B1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME (US) | 2021-10-27 | — | — | EP | disclosed |
| US-20210196734-A1 | SUBSTITUTED 6-MEMBERED ARYL OR HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2021-07-01 | — | — | US | disclosed |
| US-11026958-B2 | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors | MERCK SHARP & DOHME CORP. (US) | 2021-06-08 | — | — | US | disclosed |
| US-20210077511-A1 | SUBSTITUTED 6-MEMBERED ARYL OR HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2021-03-18 | — | — | US | disclosed |
| US-10870630-B2 | Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors | MERCK SHARP & DOHME CORP. | 2020-12-22 | — | — | US | disclosed |
| US-20190337910-A1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2019-11-07 | — | — | US | disclosed |
| US-20190308945-A1 | SUBSTITUTED BICYCLIC HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | US | disclosed |
| EP-2888229-B1 | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-02-06 | — | — | EP | disclosed |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | MERCK SHARP & DOHME CORP. | 2015-06-25 | — | — | US | disclosed |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | MERCK SHARP & DOHME CORP. | 2015-06-25 | — | — | US | disclosed |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | MERCK SHARP & DOHME CORP. | 2015-06-25 | — | — | US | disclosed |
| US-9062013-B2 | Positive allosteric modulators of the α7 nicotinic acetylcholine receptor and uses thereof | BIONOMICS LIMITED (AU) | 2015-06-23 | — | — | US | disclosed |
| EP-2207540-B1 | CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2014-02-26 | — | — | EP | disclosed |
| US-20140031395-A1 | Positive Allosteric Modulators of the Alpha 7 Nicotinic Acetylcholine Receptor and uses Thereof | BIONOMICS LIMITED (AU) | 2014-01-30 | — | — | US | disclosed |
| CN-101815512-B | Cyclopropyl aryl amide derivatives and uses thereof | HOFFMANN LA ROCHE | 2013-04-24 | — | — | CN | disclosed |
| CN-101815512-A | cyclopropyl aryl amide derivatives and uses thereof | HOFFMANN LA ROCHE | 2010-08-25 | — | — | CN | disclosed |
| US-7723391-B2 | Cyclopropyl aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090093525-A1 | Cyclopropyl aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190337910-A1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNA5, CHRNA6 | SLC9A1 3871/4885EDNRA 714/4885HDAC4 3232/4885 |
| US-11793821-B2 | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors | CHRNA7, CHRNA6, CHRNA5 | SLC9A1 4534/4885EDNRA 1282/4885HDAC4 3362/4885 |
| US-10870630-B2 | Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors | CHRNA7, CHRNA5, CHRNA2 | SLC9A1 4394/4885EDNRA 1123/4885HDAC4 3722/4885 |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | CHRNA7, CHRNA6, CHRNA5 | SLC9A1 2670/4885EDNRA 1144/4885HDAC4 3140/4885 |
| US-11026958-B2 | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors | CHRNA7, CHRNA6, CHRNA5 | SLC9A1 4518/4885EDNRA 1256/4885HDAC4 3241/4885 |
| US-20210196734-A1 | SUBSTITUTED 6-MEMBERED ARYL OR HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNA6, CHRNA5 | SLC9A1 4534/4885EDNRA 1282/4885HDAC4 3362/4885 |
| US-20210077511-A1 | SUBSTITUTED 6-MEMBERED ARYL OR HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNA6, CHRNA5 | SLC9A1 4391/4885EDNRA 1295/4885HDAC4 3420/4885 |
| US-20140031395-A1 | Positive Allosteric Modulators of the Alpha 7 Nicotinic Acetylcholine Receptor and uses Thereof | CHRNA7, CHRNA5, CHRNA10 | SLC9A1 2810/4885EDNRA 763/4885HDAC4 1298/4885 |
| US-20090093525-A1 | Cyclopropyl aryl amide derivatives and uses thereof | AR, ADRA2A, ADRA1A | SLC9A1 3094/4885EDNRA 268/4885HDAC4 844/4885 |
| US-20190308945-A1 | SUBSTITUTED BICYCLIC HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNA5, CHRNA2 | SLC9A1 4394/4885EDNRA 1123/4885HDAC4 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.