Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287857 | 1.00 | MAOB (0.39) | MAOBMAOAACHETDP1MEN1 | |
| SCHEMBL3290562 | 0.78 | MAOB (0.46) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL3289865 | 0.78 | MAOB (0.46) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL3289854 | 0.78 | MAOB (0.46) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL3289530 | 0.78 | MAOB (0.46) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL3290557 | 0.78 | MAOB (0.46) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL3286893 | 0.74 | MAOB (0.44) | MAOBMAOAMEN1KMT2AHTR2C | |
| SCHEMBL3286897 | 0.74 | MAOB (0.44) | MAOBMAOAMEN1KMT2AHTR2C | |
| SCHEMBL3286887 | 0.74 | MAOB (0.44) | MAOBMAOAMEN1KMT2AHTR2C | |
| SCHEMBL3294029 | 0.73 | CA2 (0.47) | TDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207540-B1 | CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2014-02-26 | — | — | EP | disclosed |
| CN-101815512-B | Cyclopropyl aryl amide derivatives and uses thereof | HOFFMANN LA ROCHE | 2013-04-24 | — | — | CN | disclosed |
| CN-101815512-A | cyclopropyl aryl amide derivatives and uses thereof | HOFFMANN LA ROCHE | 2010-08-25 | — | — | CN | disclosed |
| US-7723391-B2 | Cyclopropyl aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090093525-A1 | Cyclopropyl aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093525-A1 | Cyclopropyl aryl amide derivatives and uses thereof | AR, ADRA2A, ADRA1A | MAOB 778/4885MAOA 899/4885ACHE 3093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.