Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 15/20 | 0.46 |
| ▸ | MAOA | P21397 | 14/20 | 0.46 |
| ▸ | KDM1A | O60341 | 12/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290562 | 1.00 | MAOB (0.46) | MAOBMAOAKDM1ASLC9A1HTR2C | |
| SCHEMBL3290557 | 1.00 | MAOB (0.46) | MAOBMAOAKDM1ASLC9A1HTR2C | |
| SCHEMBL3289854 | 1.00 | MAOB (0.46) | MAOBMAOAKDM1ASLC9A1HTR2C | |
| SCHEMBL3289530 | 1.00 | MAOB (0.46) | MAOBMAOAKDM1ASLC9A1HTR2C | |
| SCHEMBL13328377 | 0.78 | MAOB (0.39) | MAOBMAOAKDM1AHTR2CHTR2A | |
| SCHEMBL3287865 | 0.78 | MAOB (0.39) | MAOBMAOAKDM1AHTR2CHTR2A | |
| SCHEMBL3287857 | 0.78 | MAOB (0.39) | MAOBMAOAKDM1AHTR2CHTR2A | |
| SCHEMBL10975565 | 0.77 | CHRNA7 (0.47) | MAOBMAOAKDM1ASLC9A1HTR2C | |
| SCHEMBL30312019 | 0.76 | KDM1A (0.46) | MAOBMAOAKDM1ASLC9A1HTR2C | |
| SCHEMBL30311999 | 0.75 | SLC9A1 (0.42) | MAOBMAOAKDM1ASLC9A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207540-B1 | CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2014-02-26 | — | — | EP | disclosed |
| CN-101815512-B | Cyclopropyl aryl amide derivatives and uses thereof | HOFFMANN LA ROCHE | 2013-04-24 | — | — | CN | disclosed |
| CN-101815512-A | cyclopropyl aryl amide derivatives and uses thereof | HOFFMANN LA ROCHE | 2010-08-25 | — | — | CN | disclosed |
| US-7723391-B2 | Cyclopropyl aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090093525-A1 | Cyclopropyl aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093525-A1 | Cyclopropyl aryl amide derivatives and uses thereof | AR, ADRA2A, ADRA1A | MAOB 778/4885MAOA 899/4885KDM1A 1930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.