Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495667 | 0.89 | KMT2A (0.54) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL163631 | 0.86 | TSHR (0.52) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL3996643 | 0.85 | SHMT2 (0.54) | KDM4ETDP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL161315 | 0.83 | SMN1; SMN2 (0.61) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL13295307 | 0.80 | ALDH1A1 (0.52) | KDM4EL3MBTL1TDP1MAPK1SMN1; SMN2 | |
| SCHEMBL29799053 | 0.80 | ALDH1A1 (0.52) | KDM4EL3MBTL1TDP1MAPK1SMN1; SMN2 | |
| SCHEMBL166288 | 0.78 | TSHR (0.52) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL163006 | 0.78 | KMT2A (0.42) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL163814 | 0.78 | SMN1; SMN2 (0.50) | KDM4EL3MBTL1TDP1MAPK1SMN1; SMN2 | |
| SCHEMBL9729781 | 0.78 | ALDH1A1 (0.55) | KDM4EL3MBTL1TDP1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718663-B2 | Quinazoline derivatives and medicaments | NIPPON SHINYAKU CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20050176741-A1 | Nociceptin antagonism; antipruritic effect; N-{4-[((1S,2R)-2-{[amino(imino)methyl]amino}cyclohexyl)amino]-6-methylquinazolin-2-yl}-1-benzothiophene-2-carboxamide dihydrochloride | NIPPON SHINYAKU CO., LTD. (JP) | 2005-08-11 | — | — | US | disclosed |
| EP-1500652-A1 | QUINAZOLINE DERIVATIVE AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176741-A1 | Nociceptin antagonism; antipruritic effect; N-{4-[((1S,2R)-2-{[amino(imino)methyl]amino}cyclohexyl)amino]-6-methylquinazolin-2-yl}-1-benzothiophene-2-carboxamide dihydrochloride | OPRL1, TRPV1, OPRK1 | KDM4E 3920/4885L3MBTL1 3236/4885TDP1 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.