Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | APOB | P04114 | 1/20 | 0.43 |
| ▸ | MTTP | P55157 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145537 | 0.93 | SMN1; SMN2 (0.52) | MAPTHTTSMN1; SMN2TRPV4KDM4E | |
| SCHEMBL5144167 | 0.92 | KDM4E (0.48) | MAPTHTTSMN1; SMN2TRPV4KDM4E | |
| SCHEMBL3292088 | 0.92 | MTTP (0.48) | MAPTHTTSMN1; SMN2KDM4EGAA | |
| SCHEMBL3289775 | 0.88 | POLB (0.51) | MAPTTRPV4KDM4EGAAEPHX2 | |
| SCHEMBL5144288 | 0.88 | KDM4E (0.46) | SMN1; SMN2KDM4EGAAP2RY12MMP1 | |
| SCHEMBL3289503 | 0.88 | EPHX2 (0.49) | MAPTTRPV4KDM4EGAAEPHX2 | |
| SCHEMBL3289823 | 0.85 | KDM4E (0.46) | KDM4EGAACHRM3P2RY12MMP1 | |
| SCHEMBL3290189 | 0.84 | SMN1; SMN2 (0.51) | MAPTHTTSMN1; SMN2KDM4EGAA | |
| SCHEMBL3288869 | 0.84 | MTTP (0.56) | APOBMTTP | |
| SCHEMBL3289514 | 0.83 | GAA (0.47) | HTTKDM4EGAACHRM3P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723358-B2 | Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems | MERCK PATENT GMBH (DE) | 2010-05-25 | — | — | US | claimed |
| US-20070254919-A1 | Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems | MERCK PATENT GMBH (DE) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254919-A1 | Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems | GPR119, FABP4, LIPC | MAPT 4285/4885HTT 2766/4885SMN1; SMN2 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.