Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291823 | 0.93 | GRIN1 (0.64) | GRIN1GRIN2BHTR7HTR1ADRD3 | |
| Hydrochloric Acid SCHEMBL3297784 | 0.83 | GRIN1 (0.54) | GRIN1GRIN2BHTR7HTR1ADRD3 | |
| Trifluoroacetic Acid SCHEMBL3292887 | 0.79 | GRIN1 (0.66) | GRIN1GRIN2BDRD3DRD2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5699605 | 0.79 | GRIN1 (0.66) | GRIN1GRIN2BDRD3DRD2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5699544 | 0.79 | GRIN1 (0.66) | GRIN1GRIN2BDRD3DRD2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL3291179 | 0.79 | GRIN1 (0.66) | GRIN1GRIN2BDRD3DRD2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5699540 | 0.75 | DRD2 (0.54) | GRIN1GRIN2BDRD3DRD2CHRM2 | |
| SCHEMBL3291399 | 0.75 | DRD2 (0.47) | GRIN1GRIN2BHTR7HTR1ADRD3 | |
| Trifluoroacetic Acid SCHEMBL3291917 | 0.75 | DRD2 (0.54) | GRIN1GRIN2BDRD3DRD2CHRM2 | |
| SCHEMBL3294289 | 0.75 | DRD2 (0.47) | GRIN1GRIN2BHTR7HTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723384-B2 | Keto lactam compounds and use thereof | ABBOTT GMBH & CO. KG. (DE) | 2010-05-25 | — | — | US | disclosed |
| US-20070219182-A1 | Keto Lactam Compounds and Use Thereof | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2007-09-20 | — | — | US | disclosed |
| EP-1692129-A1 | KETO LACTAM COMPOUNDS AND USE THEREOF | Abbott GmbH & Co. KG (DE) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056546-A1 | KETO LACTAM COMPOUNDS AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219182-A1 | Keto Lactam Compounds and Use Thereof | OPRD1, DRD3, OPRK1 | GRIN1 121/4885GRIN2B 497/4885HTR7 891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.