Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365536 | 0.89 | ALDH1A1 (0.39) | SCN4ACYP1A2HPGDALDH1A1 | |
| SCHEMBL5545694 | 0.69 | MAPT (0.42) | CYP1A2CYP3A4HPGDALDH1A1 | |
| SCHEMBL4620319 | 0.68 | MAPT (0.33) | SCN4AALDH1A1 | |
| SCHEMBL7740492 | 0.67 | MYC (0.33) | HTR7CYP1A2CYP3A4CYP2C9HPGD | |
| O-Xylene SCHEMBL17698412 | 0.66 | ACHE (0.62) | ADRB1OPRM1HTR2CHTR7HTR1A | |
| O-Xylene SCHEMBL9614719 | 0.66 | ACHE (0.62) | ADRB1OPRM1HTR2CHTR7HTR1A | |
| Piperazine SCHEMBL28747440 | 0.63 | HIF1A (0.40) | CYP3A4 | |
| Phosphoric Acid SCHEMBL30528979 | 0.62 | TRPA1 (0.52) | CYP1A2CYP3A4CYP2C9HPGDALDH1A1 | |
| Phosphoric Acid SCHEMBL27222307 | 0.62 | TRPA1 (0.52) | CYP1A2CYP3A4CYP2C9HPGDALDH1A1 | |
| Biphenyl SCHEMBL8466409 | 0.62 | ACP3 (0.47) | HTR7HTR1ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406307-A2 | STYRENIC POLYMER COMPOSITION | ICL-IP America Inc. (US) | 2012-01-18 | — | — | EP | claimed |
| EP-2406307-B1 | STYRENIC POLYMER COMPOSITION | ICL IP AMERICA INC (US) | 2012-12-12 | — | — | EP | disclosed |
| US-20120123007-A1 | STYRENIC POLYMER COMPOSITION | ICL-IP AMERICA INC. | 2012-05-17 | — | — | US | disclosed |
| EP-2406307-A2 | STYRENIC POLYMER COMPOSITION | ICL-IP America Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010099020-A2 | STYRENIC POLYMER COMPOSITION | ICL-IP AMERICA INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| US-7119136-B2 | Flame-retardant thermoset composition, method, and article | GENERAL ELECTRIC COMPANY (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060167142-A9 | FLAME-RETARDANT THERMOSET COMPOSITION, METHOD, AND ARTICLE | GENERAL ELECTRIC COMPANY | 2006-07-27 | — | — | US | disclosed |
| WO-2005033179-A1 | FLAME-RETARDANT THERMOSET COMPOSITION, METHOD, AND ARTICLE | GENERAL ELECTRIC COMPANY (US) | 2005-04-14 | — | — | WO | disclosed |
| US-20050075427-A1 | Flame-retardant thermoset composition, method, and article | GENERAL ELECTRIC COMPANY | 2005-04-07 | — | — | US | disclosed |