Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875573 | 1.00 | CYP1A2 (0.63) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL10059422 | 0.90 | CYP1A2 (0.57) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL3305340 | 0.86 | KDM4E (0.59) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL4860704 | 0.86 | HTT (0.55) | CYP1A2ALDH1A1HTTMAPTAR | |
| SCHEMBL10025186 | 0.84 | KDM4E (0.75) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL3305806 | 0.82 | ALDH1A1 (0.62) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL4858820 | 0.82 | MEN1 (0.45) | CYP1A2ALDH1A1HPGDHTTCYP3A4 | |
| SCHEMBL4861038 | 0.82 | HTT (0.44) | CYP1A2ALDH1A1HTTCYP3A4CYP2C19 | |
| SCHEMBL16474660 | 0.82 | HTT (0.51) | CYP1A2ALDH1A1HPGDHTTMAPT | |
| Hydrochloric Acid SCHEMBL4852356 | 0.81 | HTT (0.43) | CYP1A2ALDH1A1HTTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866656-B1 | USE OF N-SUBSTITUTED PYRIDONES AS TUMOR NECROSIS FACTOR ALPHA INHIBITORS | MARGOLIN SOLOMON B (US) | 2007-04-25 | — | — | EP | claimed |
| EP-1261338-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2006-06-14 | — | — | EP | claimed |
| EP-1069898-B1 | TOPICAL ANTISEPTIC COMPOSITIONS AND METHODS | MARGOLIN SOLOMON B (US) | 2004-05-12 | — | — | EP | claimed |
| EP-0813409-B1 | TREATMENT OF CYTOKINE GROWTH FACTOR CAUSED DISORDERS | MARGOLIN SOLOMON B (US) | 2004-05-06 | — | — | EP | claimed |
| US-5962478-A | ADMINISTERING A N-SUBSTITUTED 2(1H)PYRIDONE | INTERMUNE, INC. | 1999-10-05 | — | — | US | claimed |
| US-5716632-A | ADMINISTERING N-SUBSTITUTED 2-(1H)PYRIDONES OR 3-(1H)PYRIDONES | MARGOLIN SOLOMON B (US) | 1998-02-10 | — | — | US | claimed |
| US-5518729-A | N-SUBSTITUTED PYRIDONES | MARGOLIN SOLOMON B (US) | 1996-05-21 | — | — | US | claimed |
| US-20250114376-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | AVALYN PHARMA INC. | 2025-04-10 | — | — | US | disclosed |
| US-12226407-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | AVALYN PHARMA INC. (US) | 2025-02-18 | — | — | US | disclosed |
| US-12023342-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | AVALYN PHARMA INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-20230149375-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | AVALYN PHARMA INC. | 2023-05-18 | — | — | US | disclosed |
| US-11559520-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | AVALYN PHARMA INC. (US) | 2023-01-24 | — | — | US | disclosed |
| US-11452718-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | AVALYN PHARMA INC. (US) | 2022-09-27 | — | — | US | disclosed |
| US-6956044-B1 | Compositions and methods for treatment of epilepsy | INTERMUNE, INC. | 2005-10-18 | — | — | US | disclosed |
| US-20040029881-A1 | Substituted iminoazines | BAYER AKTIENGESELLSCHAFT (DE) | 2004-02-12 | — | — | US | disclosed |
| US-5962478-A | ADMINISTERING A N-SUBSTITUTED 2(1H)PYRIDONE | INTERMUNE, INC. | 1999-10-05 | — | — | US | disclosed |
| US-5518729-A | N-SUBSTITUTED PYRIDONES | MARGOLIN SOLOMON B (US) | 1996-05-21 | — | — | US | disclosed |
| US-4052509-A | 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1977-10-04 | — | — | US | disclosed |
| US-4042699-A | 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1977-08-16 | — | — | US | disclosed |
| US-3974281-A | ANALGESICS, ANTI-PYRETIC AND ANTI-INFLAMMATORY AGENTS | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1976-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149375-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | PLPBP, PIR, PDXK | CYP1A2 123/4885HSD17B10 2978/4885KDM4E 2879/4885 |
| US-20250114376-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | PLPBP, PIR, PDXK | CYP1A2 123/4885HSD17B10 2978/4885KDM4E 2879/4885 |
| US-20040029881-A1 | Substituted iminoazines | CYP4Z1, DDT, CYP1A1 | CYP1A2 5/4885HSD17B10 1942/4885KDM4E 3146/4885 |
| US-11559520-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | PLPBP, PIR, PDXK | CYP1A2 123/4885HSD17B10 2978/4885KDM4E 2879/4885 |
| US-11452718-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | PLPBP, PIR, PDXK | CYP1A2 123/4885HSD17B10 2978/4885KDM4E 2879/4885 |
| US-12023342-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | PLPBP, PIR, PDXK | CYP1A2 123/4885HSD17B10 2978/4885KDM4E 2879/4885 |
| US-12226407-B2 | Aerosol pirfenidone and pyridone analog compounds and uses thereof | PLPBP, PIR, PDXK | CYP1A2 123/4885HSD17B10 2978/4885KDM4E 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.