SCHEMBL3294707

SCHEMBL3294707

COc1cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(OC)cc1-c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 3/20 0.54
AKR1C2 P52895 3/20 0.54
CASR P41180 2/20 0.38
BACE1 P56817 1/20 0.38
F2RL3 Q96RI0 1/20 0.38
PSEN1 P49768 1/20 0.38
PSEN2 P49810 1/20 0.38
APH1B Q8WW43 1/20 0.38
NCSTN Q92542 1/20 0.38
APH1A Q96BI3 1/20 0.38
PSENEN Q9NZ42 1/20 0.38
NPSR1 Q6W5P4 2/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CTSA P10619 5/20 0.37
RORB Q92753 1/20 0.36
PTPN5 P54829 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3294513 0.82 AKR1C3 (0.56) AKR1C3AKR1C2CASRBACE1NPSR1
SCHEMBL23554365 0.79 AR (0.51) AKR1C3AKR1C2NPSR1RAB9ASMN1; SMN2
SCHEMBL28441006 0.78 AKR1C3 (0.50) AKR1C3AKR1C2CASRPSEN1PSEN2
SCHEMBL23554367 0.78 AKR1C3 (0.42) AKR1C3AKR1C2F2RL3PSEN1PSEN2
SCHEMBL16711690 0.77 ALDH1A1 (0.51) AKR1C3AKR1C2CASRCTSA
SCHEMBL28533166 0.77 AKR1C3 (0.55) AKR1C3AKR1C2PSEN1PSEN2APH1B
SCHEMBL26457539 0.75 L3MBTL1 (0.51) AKR1C3AKR1C2NPSR1RAB9ARORB
SCHEMBL14499450 0.72 RXRA (0.54) AKR1C3AKR1C2PSEN1PSEN2APH1B
SCHEMBL23554368 0.71 ABCG2 (0.41) AKR1C3AKR1C2NPSR1RAB9ASMN1; SMN2
SCHEMBL12964117 0.71 AKR1C3 (0.41) AKR1C3AKR1C2NPSR1RAB9ACTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060183878-A1 Terphenyl dihydroxy monomers containing fluorine and fluorinated poly(arylene ether sulfide)s GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY 2006-08-17 US claimed
US-7732560-B2 Reaction product of a 5,10-dihydroxyterphenyl, 4,4'-thiobis(tetrafluorophenol) and optionally ethynylphenol; for use in the field of hgih speed, information telecommunications and production of highly efficient materials for optical waveguides. GWANGJU INSTITUTE OF SCIENCE OF TECHNOLOGY (KR) 2010-06-08 US disclosed
US-7732560-B2 Reaction product of a 5,10-dihydroxyterphenyl, 4,4'-thiobis(tetrafluorophenol) and optionally ethynylphenol; for use in the field of hgih speed, information telecommunications and production of highly efficient materials for optical waveguides. GWANGJU INSTITUTE OF SCIENCE OF TECHNOLOGY (KR) 2010-06-08 US disclosed
US-7732560-B2 Reaction product of a 5,10-dihydroxyterphenyl, 4,4'-thiobis(tetrafluorophenol) and optionally ethynylphenol; for use in the field of hgih speed, information telecommunications and production of highly efficient materials for optical waveguides. GWANGJU INSTITUTE OF SCIENCE OF TECHNOLOGY (KR) 2010-06-08 US disclosed
US-20090259017-A1 TERPHENYL DIHYDROXY MONOMERS CONTAINING FLUORINE AND FLUORINATED POLY(ARYLENE ETHER SULFIDE)S LEE JAE-SUK 2009-10-15 US disclosed
US-20090259017-A1 TERPHENYL DIHYDROXY MONOMERS CONTAINING FLUORINE AND FLUORINATED POLY(ARYLENE ETHER SULFIDE)S LEE JAE-SUK 2009-10-15 US disclosed
US-20090259017-A1 TERPHENYL DIHYDROXY MONOMERS CONTAINING FLUORINE AND FLUORINATED POLY(ARYLENE ETHER SULFIDE)S LEE JAE-SUK 2009-10-15 US disclosed
US-20060183878-A1 Terphenyl dihydroxy monomers containing fluorine and fluorinated poly(arylene ether sulfide)s GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY 2006-08-17 US disclosed