Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NPY1R | P25929 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818024 | 0.99 | ALDH1A1 (0.33) | ALDH1A1GAAMEN1PKMKMT2A | |
| SCHEMBL3818026 | 0.99 | ALDH1A1 (0.33) | ALDH1A1GAAMEN1PKMKMT2A | |
| SCHEMBL13294218 | 0.92 | ALDH1A1 (0.32) | ALDH1A1GAAMEN1PKMKMT2A | |
| SCHEMBL13294092 | 0.81 | NPY1R (0.32) | ALDH1A1KDM4ENPY1R | |
| Hydrochloric Acid SCHEMBL3292225 | 0.76 | ALDH1A1 (0.33) | ALDH1A1GAAMEN1PKMKMT2A | |
| SCHEMBL3820056 | 0.75 | ALDH1A1 (0.33) | ALDH1A1GAAMEN1PKMKMT2A | |
| SCHEMBL3820058 | 0.75 | ALDH1A1 (0.33) | ALDH1A1GAAMEN1PKMKMT2A | |
| SCHEMBL10104223 | 0.73 | LMNA (0.33) | ALDH1A1GAAKMT2AKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3290887 | 0.73 | ATM (0.50) | ALDH1A1MEN1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL10104559 | 0.72 | NPY1R (0.33) | ALDH1A1KMT2AKDM4EMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727287-B2 | Hemicyanin styryl thiol/disulfide dye, composition comprising hemicyanin styryl thoil/disulfide dye, and method for lightening keratin materials using hemicyanin styryl thiol/disulfide dye | L'OREAL S.A. (FR) | 2010-06-01 | — | — | US | disclosed |