Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1299646 | 0.87 | TP53 (0.39) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1565868 | 0.86 | NPSR1 (0.40) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL18000528 | 0.82 | TP53 (0.46) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4756855 | 0.77 | EPHX2 (0.40) | EPHX2 | |
| SCHEMBL1773952 | 0.75 | TP53 (0.52) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1299600 | 0.75 | TSHR (0.45) | TSHRALDH1A1KDM4EPOLBCYP2C19 | |
| SCHEMBL28780703 | 0.74 | TP53 (0.47) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL12634 | 0.73 | KDM4E (0.53) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14761384 | 0.73 | TP53 (0.50) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL3699219 | 0.72 | TP53 (0.42) | TP53NPSR1SMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240189287-A1 | PERIPHERALLY RESTRICTED CB1 RECEPTOR BLOCKERS AND USES THEREOF | BIONANOSIM (BNS) LTD (IL) | 2024-06-13 | — | — | US | disclosed |
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-03-23 | — | — | US | disclosed |
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | disclosed |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-12 | — | — | US | disclosed |
| CN-108558622-A | A kind of preparation method and products thereof of novel 5- allyls cyclopentenone | 南京林业大学 | 2018-09-21 | — | — | CN | disclosed |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | US | disclosed |
| US-20100099708-A1 | Piperidine Derivative Used for Treating Chemokine Receptor 5 Mediated Diseases | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | US | disclosed |
| US-20100099708-A1 | Piperidine Derivative Used for Treating Chemokine Receptor 5 Mediated Diseases | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | US | disclosed |
| WO-2004056773-A1 | NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | WO | disclosed |
| US-20040092554-A1 | 4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists | BROTHERTON-PLEISS CHRISTINE E (US) | 2004-05-13 | — | — | US | disclosed |
| CN-1143848-C | 2-arylethyl- (piperidin-4-ylmethyl) amine derivatives as muscarinic receptor antagonists | - | 2004-03-31 | — | — | CN | disclosed |
| US-6627644-B2 | Muscarinic receptor antagonists and parasympathetic nervous system. The physiological actions of Acetylcholine are mediated by activation of either nicotinic or muscarinic receptors | SYNTEX (U.S.A.) LLC | 2003-09-30 | — | — | US | disclosed |
| US-20030162780-A1 | 4-PIPERIDINYL ALKYL AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) LLC, NAME CHANGED TO ROCHE PALO ALTO LLC | 2003-08-28 | — | — | US | disclosed |
| WO-2003048124-A1 | 4-PIPERIDINYL ALKYLAMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-12 | — | — | WO | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |
| CN-1295563-A | 2-arylethyl- (piperidin-4-ylmethyl) amine derivatives as muscarinic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-16 | — | — | CN | disclosed |
| EP-1058680-A1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999043657-A1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162780-A1 | 4-PIPERIDINYL ALKYL AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | CHRM1, CHRM3, CHRM2 | TP53 3343/4885NPSR1 32/4885SMN1; SMN2 3859/4885 |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | ROCK1, ROCK2, CIT | TP53 4673/4885NPSR1 3264/4885SMN1; SMN2 4700/4885 |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | TP53 4673/4885NPSR1 3264/4885SMN1; SMN2 4700/4885 |
| US-20040092554-A1 | 4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists | CHRM1, CHRM3, CHRM2 | TP53 3343/4885NPSR1 32/4885SMN1; SMN2 3859/4885 |
| US-20240189287-A1 | PERIPHERALLY RESTRICTED CB1 RECEPTOR BLOCKERS AND USES THEREOF | CNR1, CNR2, GPR18 | TP53 4880/4885NPSR1 19/4885SMN1; SMN2 2041/4885 |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | TP53 4673/4885NPSR1 3264/4885SMN1; SMN2 4700/4885 |
| US-20100099708-A1 | Piperidine Derivative Used for Treating Chemokine Receptor 5 Mediated Diseases | CCR5, CXCR5, CCR2 | TP53 4415/4885NPSR1 139/4885SMN1; SMN2 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.