Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.64 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.61 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.59 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.59 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167468 | 0.86 | KDR (0.57) | KDRKCNMA1TMPRSS4P2RX1P2RX4 | |
| SCHEMBL21828993 | 0.84 | GRIK1 (0.64) | RAB9AGRIK1MEN1KMT2ACHRNB2 | |
| SCHEMBL17774884 | 0.83 | NPC1 (0.63) | RAB9AMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL2743115 | 0.82 | NPC1 (0.61) | RAB9AMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL31722789 | 0.82 | NPC1 (0.61) | RAB9AMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL29575361 | 0.82 | NPC1 (0.61) | RAB9AMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL31093979 | 0.82 | KCNMA1 (0.71) | KDRKCNMA1TMPRSS4P2RX1P2RX4 | |
| SCHEMBL16147455 | 0.82 | KCNMA1 (0.71) | KDRKCNMA1TMPRSS4P2RX1P2RX4 | |
| SCHEMBL24004566 | 0.82 | GRIK1 (0.61) | RAB9AGRIK1MEN1KMT2ACHRNB2 | |
| SCHEMBL21828990 | 0.82 | RAB9A (0.72) | KCNMA1RAB9AGRIK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170057910-A1 | ANTITUMOR NAPHTHALENYL BENZAMIDE DERIVATIVES | THE CLEVELAND CLINIC FOUNDATION | 2017-03-02 | — | — | US | disclosed |
| US-20170057910-A1 | ANTITUMOR NAPHTHALENYL BENZAMIDE DERIVATIVES | THE CLEVELAND CLINIC FOUNDATION | 2017-03-02 | — | — | US | disclosed |
| US-8263657-B2 | Blocking neurokinins; using a benzene compound containing hydroxy or acetoxy group; antiinflammatory agents | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2012-09-11 | — | — | US | disclosed |
| US-8097759-B2 | Inflammatory cytokine release inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20100274051-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2010-10-28 | — | — | US | disclosed |
| US-20090192122-A2 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-07-30 | — | — | US | disclosed |
| US-20080318956-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2008-12-25 | — | — | US | disclosed |
| US-20080249071-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2008-10-09 | — | — | US | disclosed |
| EP-1847263-A2 | Inhibitors against the production and release of inflammatory cytokines | Institute of Medicinal Molecular Design, Inc. (JP) | 2007-10-24 | — | — | EP | disclosed |
| EP-1844766-A2 | Inhibitors against the production and release of inflammatory cytokines | Institute of Medicinal Molecular Design, Inc. (JP) | 2007-10-17 | — | — | EP | disclosed |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1352650-A1 | INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES | Institute of Medicinal Molecular Design, Inc. (JP) | 2003-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057910-A1 | ANTITUMOR NAPHTHALENYL BENZAMIDE DERIVATIVES | BCL3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NAT1 | KDR 2433/4885KCNMA1 1716/4885TMPRSS4 3015/4885 |
| US-20100274051-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | IL1B, NFKBIA, IL1A | KDR 3220/4885KCNMA1 3082/4885TMPRSS4 1813/4885 |
| US-20090192122-A2 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | IL1B, NFKBIA, IL1A | KDR 3373/4885KCNMA1 3380/4885TMPRSS4 1647/4885 |
| US-20080249071-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | IL1B, NFKBIA, IL1A | KDR 3373/4885KCNMA1 3380/4885TMPRSS4 1647/4885 |
| US-20080318956-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | IL1B, NFKBIA, IL1A | KDR 3373/4885KCNMA1 3380/4885TMPRSS4 1647/4885 |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | NFKBIA, IL1B, IKBKB | KDR 3150/4885KCNMA1 2705/4885TMPRSS4 3292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.