Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL3304484 | 0.89 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL22418373 | 0.87 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28214932 | 0.87 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28247967 | 0.87 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL7169119 | 0.87 | LMNA (0.63) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL516453 | 0.87 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28308438 | 0.87 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL4207428 | 0.84 | LMNA (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3309233 | 0.84 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL16106188 | 0.84 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114891844-A | Method for efficiently pretreating corncobs by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2022-08-12 | — | — | CN | claimed |
| CN-114891844-B | Method for efficiently preprocessing corncob by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2024-05-10 | — | — | CN | disclosed |
| CN-114891844-B | Method for efficiently preprocessing corncob by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2024-05-10 | — | — | CN | disclosed |
| CN-114891844-A | Method for efficiently pretreating corncobs by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-114891844-A | Method for efficiently pretreating corncobs by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2022-08-12 | — | — | CN | disclosed |