Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 4/20 | 0.64 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 3/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133508 | 0.78 | HSD17B3 (1.00) | HSD17B3PDE2AESR1ESR2MAOA | |
| SCHEMBL15842480 | 0.72 | HSD17B3 (0.53) | HSD17B3KDM4EALDH1A1GAAHPGD | |
| SCHEMBL4430101 | 0.71 | HSD17B3 (0.62) | HSD17B3PDE2AESR1ESR2MIF | |
| SCHEMBL591248 | 0.70 | HSD17B3 (0.51) | HSD17B3PDE2AESR1ESR2MIF | |
| SCHEMBL11874784 | 0.70 | HSD17B3 (0.65) | HSD17B3CA9KDM4EALDH1A1GLA | |
| SCHEMBL10762560 | 0.69 | KMT2A (0.59) | HSD17B3PDE2AESR1ESR2CA9 | |
| SCHEMBL4430097 | 0.69 | HSD17B3 (0.58) | HSD17B3PDE2AMIFCA9PKLR | |
| SCHEMBL10793877 | 0.67 | PDE2A (0.62) | HSD17B3PDE2AESR1ESR2CA9 | |
| SCHEMBL7599634 | 0.67 | KDM4E (0.62) | HSD17B3MIFCA9KDM4EALDH1A1 | |
| SCHEMBL6961168 | 0.67 | ALDH1A1 (0.55) | HSD17B3CA9KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099118-A1 | METHODS OF DETERMINING TOTAL PON1 LEVEL | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2010-04-22 | — | — | US | disclosed |