Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430097 | 0.84 | HSD17B3 (0.58) | HSD17B3PDE2ANQO1MIFCA9 | |
| SCHEMBL1133508 | 0.77 | HSD17B3 (1.00) | HSD17B3PDE2AALPIESR1ESR2 | |
| SCHEMBL3306142 | 0.71 | HSD17B3 (0.64) | HSD17B3PDE2ANQO1MIFCA9 | |
| SCHEMBL11874784 | 0.69 | HSD17B3 (0.65) | HSD17B3CA9MAOAKDM4EMEN1 | |
| SCHEMBL10789370 | 0.66 | ESR2 (0.64) | HSD17B3PDE2ANQO1CA9PKLR | |
| SCHEMBL11880763 | 0.66 | ESR2 (0.59) | HSD17B3PDE2AESR1ESR2MAOA | |
| SCHEMBL11879798 | 0.66 | ALDH1A1 (0.59) | HSD17B3MIFNPSR1MAOAKDM4E | |
| SCHEMBL3338122 | 0.66 | ALPI (0.66) | HSD17B3ALPIMAOAMAOB | |
| SCHEMBL31366988 | 0.65 | HSD17B3 (1.00) | HSD17B3PDE2ACA9PKLRNPSR1 | |
| SCHEMBL591899 | 0.65 | HSD17B3 (1.00) | HSD17B3PDE2ACA9PKLRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134858-A1 | METHODS OF DETERMINING TOTAL PON1 LEVEL | Yeda Research And Development Company Limited (IL) | 2009-12-23 | — | — | EP | claimed |
| WO-2008111062-A1 | METHODS OF DETERMINING TOTAL PON1 LEVEL | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-18 | — | — | WO | claimed |