SCHEMBL3306459

SCHEMBL3306459

COC(=O)CC(Nc1ccc(OC)cc1)c1ccccc1[N+](=O)[O-]

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
HPGD P15428 1/20 0.46
PTPN1 P18031 1/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
MAPT P10636 3/20 0.45
LMNA P02545 3/20 0.45
NPC1 O15118 4/20 0.44
RAB9A P51151 3/20 0.44
KMT2A Q03164 2/20 0.44
GAA P10253 2/20 0.44
MAPK1 P28482 1/20 0.43
CYP1A2 P05177 1/20 0.42
TSHR P16473 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
HTT P42858 1/20 0.41
MMP1 P03956 1/20 0.41
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41
MMP13 P45452 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3306466 0.81 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2MAPTNPC1RAB9A
SCHEMBL3307472 0.79 KMT2A (0.52) ALDH1A1SMN1; SMN2MAPTLMNANPC1
SCHEMBL13414003 0.79 IDO1 (0.40) ALDH1A1SMN1; SMN2MAPTLMNANPC1
SCHEMBL3308208 0.77 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2MAPTLMNANPC1
SCHEMBL6673473 0.76 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2MAPTKMT2AGAA
Hydrochloric Acid SCHEMBL7175545 0.75 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2MAPTKMT2AGAA
SCHEMBL5853954 0.75 ALDH1A1 (0.58) ALDH1A1HPGDSMN1; SMN2MAPTLMNA
SCHEMBL5595476 0.73 CYP1A2 (0.56) ALDH1A1HPGDPTPN1SMN1; SMN2MAPT
SCHEMBL7361148 0.72 ALDH1A1 (0.46) ALDH1A1HPGDPTPN1SMN1; SMN2MAPT
SCHEMBL29157097 0.71 CTSA (0.43) ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100099886-A1 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF β-AMINO ACID ESTER DERIVATIVE AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH 2010-04-22 US disclosed
US-20100099886-A1 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF β-AMINO ACID ESTER DERIVATIVE AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH 2010-04-22 US disclosed
EP-2139873-A1 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF ß-AMINO ACID ESTER DERIVATIVE Agency for Science, Technology and Research (SG) 2010-01-06 EP disclosed
WO-2008115149-A9 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF β -AMINO ACID ESTER DERIVATIVE AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2009-10-15 WO disclosed
WO-2008115149-A1 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF β -AMINO ACID ESTER DERIVATIVE AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2008-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099886-A1 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF β-AMINO ACID ESTER DERIVATIVE DDC, NDC1, ADH1C ALDH1A1 60/4885HPGD 47/4885PTPN1 3475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.