Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.87 |
| ▸ | MEN1 | O00255 | 5/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | APEX1 | P27695 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL5693169 | 0.97 | — | — | |
| Choline SCHEMBL9954387 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL10765928 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL8740329 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL11098179 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL326078 | 0.97 | — | — | |
| Choline SCHEMBL11228907 | 0.97 | — | — | |
| Choline SCHEMBL18074133 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL8934710 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL4947440 | 0.97 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108070337-A | A kind of preparation method of the compound special conducting resinl of LED chip | 成都新柯力化工科技有限公司 | 2018-05-25 | — | — | CN | claimed |
| EP-1658361-A1 | LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2006-05-24 | — | — | EP | claimed |
| WO-2005021698-A1 | LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2005-03-10 | — | — | WO | claimed |
| US-20050049161-A1 | LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY | 2005-03-03 | — | — | US | claimed |
| EP-1485457-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1485455-A1 | FOAMSTABLE ANTIMICROBIAL LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1485454-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2004-12-15 | — | — | EP | claimed |
| US-20040101504-A1 | Mild antibacterial liquid dish cleaning composition having improved stability | COLGATE-PALMOLIVE COMPANY | 2004-05-27 | — | — | US | claimed |
| WO-2003080786-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080784-A1 | FOAMSTABLE ANTIMICROBIAL LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080783-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |
| US-20030144218-A1 | Mild antibacterial liquid dish cleaning compositions having improved stability | COLGATE-PALMOLIVE COMPANY | 2003-07-31 | — | — | US | claimed |
| US-20030144170-A1 | Antibacterial liquid dish cleaning compositions | COLGATE-PALMOLIVE COMPANY | 2003-07-31 | — | — | US | claimed |
| US-20020197293-A1 | Antibacterial liquid dish cleaning compositions having improved viscosity | COLGATE-PALMOLIVE COMPANY | 2002-12-26 | — | — | US | claimed |
| US-20020198130-A1 | Antibacterial liquid dish cleaning compositions | COLGATE-PALMOLIVE COMPANY | 2002-12-26 | — | — | US | claimed |
| WO-2002092743-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS HAVING IMPROVED VISCOSITY | COLGATE-PALMOLIVE COMPANY (US) | 2002-11-21 | — | — | WO | claimed |
| CN-116251137-B | Method for extracting flavonoid compounds from caulis spatholobi | 北京农学院 | 2024-01-30 | — | — | CN | disclosed |
| CN-116251137-A | Method for extracting flavonoid compounds from caulis spatholobi | 北京农学院 | 2023-06-13 | — | — | CN | disclosed |
| EP-1658361-A1 | LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005021698-A1 | LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020197293-A1 | Antibacterial liquid dish cleaning compositions having improved viscosity | ERG28, CXCL8, EBP | CYP3A4 3969/4885SLC5A7 313/4885MEN1 4138/4885 |
| US-20040101504-A1 | Mild antibacterial liquid dish cleaning composition having improved stability | UGT8, SPOUT1, ERG28 | CYP3A4 3951/4885SLC5A7 778/4885MEN1 3315/4885 |
| US-20030144218-A1 | Mild antibacterial liquid dish cleaning compositions having improved stability | UGT8, SPOUT1, ERG28 | CYP3A4 4035/4885SLC5A7 703/4885MEN1 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.